Structural Constraints and Emergence of Sequence Patterns in Protein Evolution Export

@article{citeulike:752868, abstract = {The aim of this work was to study the relationship between structure conservation and sequence divergence in protein evolution. To this end, we developed a model of structurally constrained protein evolution (SCPE) in which trial sequences, generated by random mutations at gene level, are selected against departure from a reference three-dimensional structure. Since at the mutational level SCPE is completely unbiased, any emergent sequence pattern will be due exclusively to structural constraints. In this first report, it is shown that SCPE correctly predicts the characteristic hexapeptide motif of the left-handed parallel {beta} helix (L{beta}H) domain of UDP-N-acetylglucosamine acyltransferases (LpxA).}, address = {Universidad Nacional de Quilmes, Bernal, Argentina.}, author = {Parisi, Gustavo and Echave, Julian}, citeulike-article-id = {752868}, citeulike-linkout-0 = {http://mbe.oxfordjournals.org/cgi/content/abstract/18/5/750}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11319259}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11319259}, day = {1}, issn = {0737-4038}, journal = {Mol Biol Evol}, keywords = {proteins}, month = {May}, number = {5}, pages = {750--756}, posted-at = {2009-09-21 19:30:09}, priority = {2}, title = {Structural Constraints and Emergence of Sequence Patterns in Protein Evolution}, url = {http://mbe.oxfordjournals.org/cgi/content/abstract/18/5/750}, volume = {18}, year = {2001} }

TY - JOUR ID - citeulike:752868 L3 - citeulike-article-id:752868 N2 - The aim of this work was to study the relationship between structure conservation and sequence divergence in protein evolution. To this end, we developed a model of structurally constrained protein evolution (SCPE) in which trial sequences, generated by random mutations at gene level, are selected against departure from a reference three-dimensional structure. Since at the mutational level SCPE is completely unbiased, any emergent sequence pattern will be due exclusively to structural constraints. In this first report, it is shown that SCPE correctly predicts the characteristic hexapeptide motif of the left-handed parallel {beta} helix (L{beta}H) domain of UDP-N-acetylglucosamine acyltransferases (LpxA). IS - 5 JF - Mol Biol Evol SN - 0737-4038 AD - Universidad Nacional de Quilmes, Bernal, Argentina. EP - 756 TI - Structural Constraints and Emergence of Sequence Patterns in Protein Evolution VL - 18 SP - 750 KW - proteins AU - Parisi, Gustavo AU - Echave, Julian PY - 2001/05/01/ UR - http://mbe.oxfordjournals.org/cgi/content/abstract/18/5/750 ER -