Chromosome segregation and genomic stability. Export

@article{citeulike:1198590, abstract = {The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer remains circumstantial. Nonetheless, the ubiquity of aneuploidy in human cancers, particularly solid tumors, suggests a fundamental link between errors in chromosome segregation and tumorigenesis. Current research in the field is focused on elucidating the molecular basis of CIN, including the possible roles of defects in the spindle checkpoint and other regulators of mitosis.}, address = {Department of Biology, Cambridge, Massachusetts 02139, USA.}, author = {Draviam, V. M. and Xie, S. and Sorger, P. K.}, citeulike-article-id = {1198590}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.gde.2004.02.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15196457}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15196457}, doi = {10.1016/j.gde.2004.02.007}, issn = {0959-437X}, journal = {Curr Opin Genet Dev}, keywords = {cancer, chromosome\_segregation}, month = {April}, number = {2}, pages = {120--125}, posted-at = {2007-12-20 17:14:02}, priority = {2}, title = {Chromosome segregation and genomic stability.}, url = {http://dx.doi.org/10.1016/j.gde.2004.02.007}, volume = {14}, year = {2004} }

TY - JOUR ID - citeulike:1198590 L3 - citeulike-article-id:1198590 N2 - The acquisition of genomic instability is a crucial step in the development of human cancer. Genomic instability has multiple causes of which chromosomal instability (CIN) and microsatellite instability (MIN) have received the most attention. Whereas the connection between a MIN phenotype and cancer is now proven, the argument that CIN causes cancer remains circumstantial. Nonetheless, the ubiquity of aneuploidy in human cancers, particularly solid tumors, suggests a fundamental link between errors in chromosome segregation and tumorigenesis. Current research in the field is focused on elucidating the molecular basis of CIN, including the possible roles of defects in the spindle checkpoint and other regulators of mitosis. IS - 2 JF - Curr Opin Genet Dev SN - 0959-437X AD - Department of Biology, Cambridge, Massachusetts 02139, USA. EP - 125 TI - Chromosome segregation and genomic stability. VL - 14 SP - 120 KW - cancer KW - chromosome_segregation AU - Draviam, VM AU - Xie, S AU - Sorger, PK PY - 2004/04// UR - http://dx.doi.org/10.1016/j.gde.2004.02.007 ER -