An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis Export

@article{liuPNAS08, abstract = {10.1073/pnas.0807007105 During mitosis, chromosomes undergo a series of movements while being end-on attached to the kinetochore microtubules (KMTs) from spindle poles. The mechanism underlying such movements and their physiological functions remains elusive. We describe a mechanobiochemical feedback model of chromosome motility. The key ingredient is a feedback mechanism between the local chemical reactions that control the dynamics of KMTs and the mechanical state of the chromosome via tension-sensitive proteins localized at the kinetochores. This model can recapitulate all of the essential and distinct features of chromosome motilities from prometaphase to anaphase in a coherent manner. We further show that this feedback mechanism provides robust and precise means of guiding the chromosome to the cell equator regardless of the initial conditions and uncertainty in velocity. Predictions of our model can be tested experimentally.}, author = {Liu, Jian and Desai, Arshad and Onuchic, Jos\'{e} N. and Hwa, Terence}, citeulike-article-id = {3279724}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0807007105}, citeulike-linkout-1 = {http://www.pnas.org/content/105/37/13752.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/105/37/13752.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18780795}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18780795}, doi = {10.1073/pnas.0807007105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {chromosome\_segregation}, number = {37}, pages = {13752--13757}, posted-at = {2008-09-17 13:45:59}, priority = {5}, title = {An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis}, url = {http://dx.doi.org/10.1073/pnas.0807007105}, volume = {105}, year = {2008} }

TY - JOUR ID - liuPNAS08 L3 - citeulike-article-id:3279724 N2 - 10.1073/pnas.0807007105 During mitosis, chromosomes undergo a series of movements while being end-on attached to the kinetochore microtubules (KMTs) from spindle poles. The mechanism underlying such movements and their physiological functions remains elusive. We describe a mechanobiochemical feedback model of chromosome motility. The key ingredient is a feedback mechanism between the local chemical reactions that control the dynamics of KMTs and the mechanical state of the chromosome via tension-sensitive proteins localized at the kinetochores. This model can recapitulate all of the essential and distinct features of chromosome motilities from prometaphase to anaphase in a coherent manner. We further show that this feedback mechanism provides robust and precise means of guiding the chromosome to the cell equator regardless of the initial conditions and uncertainty in velocity. Predictions of our model can be tested experimentally. IS - 37 JF - Proceedings of the National Academy of Sciences EP - 13757 TI - An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis VL - 105 SP - 13752 KW - chromosome_segregation AU - Liu, Jian AU - Desai, Arshad AU - Onuchic, José AU - Hwa, Terence PY - 2008//16/ UR - http://dx.doi.org/10.1073/pnas.0807007105 ER -