Common aging pathways in worms, flies, mice and humans Export

@article{citeulike:1940713, abstract = {Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species. 10.1242/jeb.004887}, author = {Kim, Stuart K.}, citeulike-article-id = {1940713}, citeulike-linkout-0 = {http://dx.doi.org/10.1242/jeb.004887}, citeulike-linkout-1 = {http://jeb.biologists.org/cgi/content/abstract/210/9/1607}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17449826}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17449826}, doi = {10.1242/jeb.004887}, journal = {J Exp Biol}, keywords = {aging, comparative, genomics, review}, month = {May}, number = {9}, pages = {1607--1612}, posted-at = {2009-06-22 15:47:38}, priority = {2}, title = {Common aging pathways in worms, flies, mice and humans}, url = {http://dx.doi.org/10.1242/jeb.004887}, volume = {210}, year = {2007} }

TY - JOUR ID - citeulike:1940713 L3 - citeulike-article-id:1940713 N2 - Development of functional genomics tools has made it possible to define the aging process by performing genome-wide scans for transcriptional differences between the young and the old. Global screens for age regulation have been performed for worms and flies, as well as many tissues in mice and humans. Recent work has begun to analyze the similarities and differences in transcriptional changes in aging among different species. Most age-related expression changes are specific for a given species, but genes in one pathway (the electron transport chain pathway) show common age regulation in species from worms to humans. Evolutionary theories of aging provide a basis to understand how age regulation of a genetic pathway might be preserved between distantly related species. 10.1242/jeb.004887 IS - 9 JF - J Exp Biol EP - 1612 TI - Common aging pathways in worms, flies, mice and humans VL - 210 SP - 1607 KW - aging KW - comparative KW - genomics KW - review AU - Kim, Stuart PY - 2007/05/01/ UR - http://dx.doi.org/10.1242/jeb.004887 ER -