Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Export

@article{citeulike:5877550, abstract = {Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging.}, author = {Selman, Colin and Tullet, Jennifer M. and Wieser, Daniela and Irvine, Elaine and Lingard, Steven J. and Choudhury, Agharul I. and Claret, Marc and Al-Qassab, Hind and Carmignac, Danielle and Ramadani, Faruk and Woods, Angela and Robinson, Iain C. and Schuster, Eugene and Batterham, Rachel L. and Kozma, Sara C. and Thomas, George and Carling, David and Okkenhaug, Klaus and Thornton, Janet M. and Partridge, Linda and Gems, David and Withers, Dominic J.}, citeulike-article-id = {5877550}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1177221}, citeulike-linkout-1 = {http://www.sciencemag.org/content/326/5949/140.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/326/5949/140.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19797661}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19797661}, day = {2}, doi = {10.1126/science.1177221}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {aging, kinase, longevity, s6, signaling}, month = {October}, number = {5949}, pages = {140--144}, posted-at = {2009-10-04 18:13:32}, priority = {2}, title = {Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.}, url = {http://dx.doi.org/10.1126/science.1177221}, volume = {326}, year = {2009} }

TY - JOUR ID - citeulike:5877550 L3 - citeulike-article-id:5877550 N2 - Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear. We show in mice that deletion of ribosomal S6 protein kinase 1 (S6K1), a component of the nutrient-responsive mTOR (mammalian target of rapamycin) signaling pathway, led to increased life span and resistance to age-related pathologies, such as bone, immune, and motor dysfunction and loss of insulin sensitivity. Deletion of S6K1 induced gene expression patterns similar to those seen in CR or with pharmacological activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), a conserved regulator of the metabolic response to CR. Our results demonstrate that S6K1 influences healthy mammalian life-span and suggest that therapeutic manipulation of S6K1 and AMPK might mimic CR and could provide broad protection against diseases of aging. IS - 5949 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 144 TI - Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. VL - 326 SP - 140 KW - aging KW - kinase KW - longevity KW - s6 KW - signaling AU - Selman, Colin AU - Tullet, Jennifer AU - Wieser, Daniela AU - Irvine, Elaine AU - Lingard, Steven AU - Choudhury, Agharul AU - Claret, Marc AU - Al-Qassab, Hind AU - Carmignac, Danielle AU - Ramadani, Faruk AU - Woods, Angela AU - Robinson, Iain AU - Schuster, Eugene AU - Batterham, Rachel AU - Kozma, Sara AU - Thomas, George AU - Carling, David AU - Okkenhaug, Klaus AU - Thornton, Janet AU - Partridge, Linda AU - Gems, David AU - Withers, Dominic PY - 2009/10/02/ UR - http://dx.doi.org/10.1126/science.1177221 ER -