IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. Export

@article{citeulike:5883289, abstract = {IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-kappaB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-kappaB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-kappaB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.}, author = {Luo, Jun-Li L. and Kamata, Hideaki and Karin, Michael}, citeulike-article-id = {5883289}, citeulike-linkout-0 = {http://dx.doi.org/10.1172/JCI26322}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16200195}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16200195}, doi = {10.1172/JCI26322}, issn = {0021-9738}, journal = {The Journal of clinical investigation}, keywords = {nfkb, review, signaling}, month = {October}, number = {10}, pages = {2625--2632}, posted-at = {2009-10-04 00:25:07}, priority = {2}, title = {IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy.}, url = {http://dx.doi.org/10.1172/JCI26322}, volume = {115}, year = {2005} }

TY - JOUR ID - citeulike:5883289 L3 - citeulike-article-id:5883289 N2 - IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-kappaB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-kappaB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-kappaB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression. IS - 10 JF - The Journal of clinical investigation SN - 0021-9738 EP - 2632 TI - IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. VL - 115 SP - 2625 KW - nfkb KW - review KW - signaling AU - Luo, Jun-Li AU - Kamata, Hideaki AU - Karin, Michael PY - 2005/10// UR - http://dx.doi.org/10.1172/JCI26322 ER -