Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature Export

@article{citeulike:812984, abstract = {We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the transcriptional profile of muscle aging to previous transcriptional profiles of aging in the kidney and the brain, and found a common signature for aging in these diverse human tissues. The common aging signature consists of six genetic pathways; four pathways increase expression with age (genes in the extracellular matrix, genes involved in cell growth, genes encoding factors involved in complement activation, and genes encoding components of the cytosolic ribosome), while two pathways decrease expression with age (genes involved in chloride transport and genes encoding subunits of the mitochondrial electron transport chain). We also compared transcriptional profiles of aging in humans to those of the mouse and fly, and found that the electron transport chain pathway decreases expression with age in all three organisms, suggesting that this may be a public marker for aging across species.}, author = {Zahn, Jacob M. and Sonu, Rebecca and Vogel, Hannes and Crane, Emily and Mazan-Mamczarz, Krystyna and Rabkin, Ralph and Davis, Ronald W. and Becker, Kevin G. and Owen, Art B. and Kim, Stuart K.}, citeulike-article-id = {812984}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.0020115}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16789832}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16789832}, day = {1}, doi = {10.1371/journal.pgen.0020115}, journal = {PLoS Genetics}, keywords = {aging, expression, gene, human, microarray, muscle}, month = {July}, number = {7}, pages = {e115+}, posted-at = {2009-06-22 15:43:05}, priority = {2}, title = {Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature}, url = {http://dx.doi.org/10.1371/journal.pgen.0020115}, volume = {2}, year = {2006} }

TY - JOUR ID - citeulike:812984 L3 - citeulike-article-id:812984 N2 - We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the transcriptional profile of muscle aging to previous transcriptional profiles of aging in the kidney and the brain, and found a common signature for aging in these diverse human tissues. The common aging signature consists of six genetic pathways; four pathways increase expression with age (genes in the extracellular matrix, genes involved in cell growth, genes encoding factors involved in complement activation, and genes encoding components of the cytosolic ribosome), while two pathways decrease expression with age (genes involved in chloride transport and genes encoding subunits of the mitochondrial electron transport chain). We also compared transcriptional profiles of aging in humans to those of the mouse and fly, and found that the electron transport chain pathway decreases expression with age in all three organisms, suggesting that this may be a public marker for aging across species. IS - 7 JF - PLoS Genetics TI - Transcriptional Profiling of Aging in Human Muscle Reveals a Common Aging Signature VL - 2 SP - e115 KW - aging KW - expression KW - gene KW - human KW - microarray KW - muscle AU - Zahn, Jacob AU - Sonu, Rebecca AU - Vogel, Hannes AU - Crane, Emily AU - Mazan-Mamczarz, Krystyna AU - Rabkin, Ralph AU - Davis, Ronald AU - Becker, Kevin AU - Owen, Art AU - Kim, Stuart PY - 2006/07/01/ UR - http://dx.doi.org/10.1371/journal.pgen.0020115 ER -