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The site of action potential initiation in cerebellar Purkinje neurons. Export

Nat Neurosci, Vol. 8, No. 2. (February 2005), pp. 137-139.

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Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.


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