The pathogenesis and management of hypertension in diabetic kidney disease.

Hypertension is one of the hallmark features of diabetic kidney disease. It contributes to both the progression of kidney disease and the risk for cardiovascular events in these patients. Although lowering blood pressure is critical in managing diabetic kidney disease, the ability to achieve this goal is complicated by the complexity of blood pressure regulation in these patients related to both extracellular volume expansion and increased vasoconstriction. This review includes a discussion of our current understanding of the etiology of hypertension in patients with diabetic kidney disease and an update of the most current clinical trials investigating antihypertensive interventions. Copyright © 2013 Elsevier Inc. All rights reserved.