Obesity and diabetic kidney disease.

Obesity and diabetes are major health concerns worldwide. Along with other elements of the metabolic syndrome, including hypertension, they contribute to the development and progression of renal disease, which, if not treated, may lead to end-stage renal disease (ESRD). Although early intervention and management of body weight, hyperglycemia, and hypertension are imperative, novel therapeutic approaches are also necessary to reduce the high morbidity and mortality associated with renal disease. This review provides perspectives regarding the mechanisms by which obesity may lead to ESRD and discusses prevention strategies and treatment of obesity-related renal disease. Copyright © 2013 Elsevier Inc. All rights reserved.