Tachyon search speeds up retrieval of similar sequences by several orders of magnitude.
by: Joshua Tan, Durga Kuchibhatla, Fernanda L. Sirota, Westley A. Sherman, Tobias Gattermayer, Chia Yee Y. Kwoh, Frank Eisenhaber, Georg Schneider, Sebastian Maurer-Stroh
Bioinformatics (Oxford, England), Vol. 28, No. 12. (15 June 2012), pp. 1645-1646, doi:10.1093/bioinformatics/bts197 Key: citeulike:12046483
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Abstract
The usage of current sequence search tools becomes increasingly slower as databases of protein sequences continue to grow exponentially. Tachyon, a new algorithm that identifies closely related protein sequences ~200 times faster than standard BLAST, circumvents this limitation with a reduced database and oligopeptide matching heuristic. AVAILABILITY AND IMPLEMENTATION: The tool is publicly accessible as a webserver at http://tachyon.bii.a-star.edu.sg and can also be accessed programmatically through SOAP.
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