Type 2 Diabetes Whole-Genome Association Study in Four Populations: The DiaGen Consortium. Export

@article{citeulike:1542403, abstract = {Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region.}, address = {Oy Jurilab, University of Kuopio, Kuopio, Finland.}, author = {Salonen, J. T. and Uimari, P. and Aalto, J. M. and Pirskanen, M. and Kaikkonen, J. and Todorova, B. and Hypponen, J. and Korhonen, V. P. and Asikainen, J. and Devine, C. and Tuomainen, T. P. and Luedemann, J. and Nauck, M. and Kerner, W. and Stephens, R. H. and New, J. P. and Ollier, W. E. and Gibson, J. M. and Payton, A. and Horan, M. A. and Pendleton, N. and Mahoney, W. and Meyre, D. and Delplanque, J. and Froguel, P. and Luzzatto, O. and Yakir, B. and Darvasi, A.}, citeulike-article-id = {1542403}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/520599}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17668382}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17668382}, doi = {10.1086/520599}, issn = {0002-9297}, journal = {Am J Hum Genet}, month = {August}, number = {2}, pages = {338--345}, posted-at = {2007-08-08 06:58:51}, priority = {2}, title = {Type 2 Diabetes Whole-Genome Association Study in Four Populations: The DiaGen Consortium.}, url = {http://dx.doi.org/10.1086/520599}, volume = {81}, year = {2007} }

TY - JOUR ID - citeulike:1542403 L3 - citeulike-article-id:1542403 N2 - Type 2 diabetes (T2D) is a common, polygenic chronic disease with high heritability. The purpose of this whole-genome association study was to discover novel T2D-associated genes. We genotyped 500 familial cases and 497 controls with >300,000 HapMap-derived tagging single-nucleotide-polymorphism (SNP) markers. When a stringent statistical correction for multiple testing was used, the only significant SNP was at TCF7L2, which has already been discovered and confirmed as a T2D-susceptibility gene. For a replication study, we selected 10 SNPs in six chromosomal regions with the strongest association (singly or as part of a haplotype) for retesting in an independent case-control set including 2,573 T2D cases and 2,776 controls. The most significant replicated result was found at the AHI1-LOC441171 gene region. IS - 2 JF - Am J Hum Genet SN - 0002-9297 AD - Oy Jurilab, University of Kuopio, Kuopio, Finland. EP - 345 TI - Type 2 Diabetes Whole-Genome Association Study in Four Populations: The DiaGen Consortium. VL - 81 SP - 338 AU - Salonen, JT AU - Uimari, P AU - Aalto, JM AU - Pirskanen, M AU - Kaikkonen, J AU - Todorova, B AU - Hypponen, J AU - Korhonen, VP AU - Asikainen, J AU - Devine, C AU - Tuomainen, TP AU - Luedemann, J AU - Nauck, M AU - Kerner, W AU - Stephens, RH AU - New, JP AU - Ollier, WE AU - Gibson, JM AU - Payton, A AU - Horan, MA AU - Pendleton, N AU - Mahoney, W AU - Meyre, D AU - Delplanque, J AU - Froguel, P AU - Luzzatto, O AU - Yakir, B AU - Darvasi, A PY - 2007/08// UR - http://dx.doi.org/10.1086/520599 ER -