The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Export

@article{citeulike:3733818, abstract = {The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.}, author = {Morrison, Deborah K.}, citeulike-article-id = {3733818}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tcb.2008.10.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0962892408002717}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19027299}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19027299}, day = {20}, doi = {10.1016/j.tcb.2008.10.003}, issn = {1879-3088}, journal = {Trends in cell biology}, keywords = {14-3-3, growth, mtor}, month = {January}, number = {1}, pages = {16--23}, posted-at = {2008-12-02 01:32:31}, priority = {2}, title = {The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.}, url = {http://dx.doi.org/10.1016/j.tcb.2008.10.003}, volume = {19}, year = {2009} }

TY - JOUR ID - citeulike:3733818 L3 - citeulike-article-id:3733818 N2 - The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis. IS - 1 JF - Trends in cell biology SN - 1879-3088 EP - 23 TI - The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. VL - 19 SP - 16 KW - 14-3-3 KW - growth KW - mtor AU - Morrison, Deborah PY - 2009/01/20/ UR - http://dx.doi.org/10.1016/j.tcb.2008.10.003 ER -