Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning. Export

@article{citeulike:3874839, abstract = {In contrast to arsenicosis caused by consumption of water contaminated by naturally occurring inorganic arsenic, human exposure to this metalloid through coal burning has been rarely reported. In this study, arsenic speciation and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in urine were determined in the Chinese residents exposed to arsenic through coal burning in Guizhou, China, an epidemic area of chronic arsenic poisoning caused by coal burning. The urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and total arsenic (tAs) of high-arsenic exposed subjects were significantly higher than those of low-arsenic exposed residents. A biomarker of oxidative DNA damage, urinary 8-OHdG level was significantly higher in high-arsenic exposed subjects than that of low exposed. Significant positive correlations were found between 8-OHdG levels and concentrations of iAs, MMA, DMA and tAs, respectively. In addition, a significant negative correlation was observed between 8-OHdG levels and the secondary methylation ratio (DMA/(MMA + DMA)). The results suggest that chronic arsenic exposure through burning coal rich in arsenic is associated with oxidative DNA damages, and that secondary methylation capacity is potentially related to the susceptibility of individuals to oxidative DNA damage induced by arsenic exposure through coal burning in domestic living.}, author = {Li, X. and Pi, J. and Li, B. and Xu, Y. and Jin, Y. and Sun, G.}, citeulike-article-id = {3874839}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00128-008-9471-0}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18575795}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18575795}, doi = {10.1007/s00128-008-9471-0}, issn = {0007-4861}, journal = {Bulletin of environmental contamination and toxicology}, keywords = {8ohdg, arsenic, china, urine}, month = {October}, number = {4}, pages = {406--411}, posted-at = {2009-01-12 03:13:40}, priority = {2}, title = {Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning.}, url = {http://dx.doi.org/10.1007/s00128-008-9471-0}, volume = {81}, year = {2008} }

TY - JOUR ID - citeulike:3874839 L3 - citeulike-article-id:3874839 N2 - In contrast to arsenicosis caused by consumption of water contaminated by naturally occurring inorganic arsenic, human exposure to this metalloid through coal burning has been rarely reported. In this study, arsenic speciation and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in urine were determined in the Chinese residents exposed to arsenic through coal burning in Guizhou, China, an epidemic area of chronic arsenic poisoning caused by coal burning. The urinary concentrations of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA) and total arsenic (tAs) of high-arsenic exposed subjects were significantly higher than those of low-arsenic exposed residents. A biomarker of oxidative DNA damage, urinary 8-OHdG level was significantly higher in high-arsenic exposed subjects than that of low exposed. Significant positive correlations were found between 8-OHdG levels and concentrations of iAs, MMA, DMA and tAs, respectively. In addition, a significant negative correlation was observed between 8-OHdG levels and the secondary methylation ratio (DMA/(MMA + DMA)). The results suggest that chronic arsenic exposure through burning coal rich in arsenic is associated with oxidative DNA damages, and that secondary methylation capacity is potentially related to the susceptibility of individuals to oxidative DNA damage induced by arsenic exposure through coal burning in domestic living. IS - 4 JF - Bulletin of environmental contamination and toxicology SN - 0007-4861 EP - 411 TI - Urinary arsenic speciation and its correlation with 8-OHdG in Chinese residents exposed to arsenic through coal burning. VL - 81 SP - 406 KW - 8ohdg KW - arsenic KW - china KW - urine AU - Li, X AU - Pi, J AU - Li, B AU - Xu, Y AU - Jin, Y AU - Sun, G PY - 2008/10// UR - http://dx.doi.org/10.1007/s00128-008-9471-0 ER -