Gene-environment interaction in genome-wide association studies. Export

@article{citeulike:3883940, abstract = {It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analysis of genome-wide association study data aimed at identifying genes involved in a gene-environment interaction. The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously.}, author = {Murcray, C. E. and Lewinger, J. P. and Gauderman, W. J.}, citeulike-article-id = {3883940}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/aje/kwn353}, citeulike-linkout-1 = {http://aje.oxfordjournals.org/cgi/content/abstract/169/2/219}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19022827}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19022827}, day = {15}, doi = {10.1093/aje/kwn353}, issn = {1476-6256}, journal = {American journal of epidemiology}, keywords = {gene-environment, gwa}, month = {January}, number = {2}, pages = {219--226}, posted-at = {2009-02-18 02:44:31}, priority = {2}, title = {Gene-environment interaction in genome-wide association studies.}, url = {http://dx.doi.org/10.1093/aje/kwn353}, volume = {169}, year = {2009} }

TY - JOUR ID - citeulike:3883940 L3 - citeulike-article-id:3883940 N2 - It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analysis of genome-wide association study data aimed at identifying genes involved in a gene-environment interaction. The procedure complements screening for marginal genetic effects and thus has the potential to uncover new genetic signals that have not been identified previously. IS - 2 JF - American journal of epidemiology SN - 1476-6256 EP - 226 TI - Gene-environment interaction in genome-wide association studies. VL - 169 SP - 219 KW - gene-environment KW - gwa AU - Murcray, CE AU - Lewinger, JP AU - Gauderman, WJ PY - 2009/01/15/ UR - http://dx.doi.org/10.1093/aje/kwn353 ER -