Endocytic regulation of TGF-beta signaling. Export

@article{citeulike:3986671, abstract = {Transforming growth factor-beta (TGF-beta) signaling is tightly regulated to ensure its proper physiological functions in different cells and tissues. Like other cell surface receptors, TGF-beta receptors are internalized into the cell, and this process plays an important regulatory role in TGF-beta signaling. It is well documented that TGF-beta receptors are endocytosed via clathrin-coated vesicles as TGF-beta endocytosis can be blocked by potassium depletion and the GTPase-deficient dynamin K44A mutant. TGF-beta receptors may also enter cells via cholesterol-rich membrane microdomain lipid rafts/caveolae and are found in caveolin-1-positive vesicles. Although receptor endocytosis is not essential for TGF-beta signaling, clathrin-mediated endocytosis has been shown to promote TGF-beta-induced Smad activation and transcriptional responses. Lipid rafts/caveolae are widely regarded as signaling centers for G protein-coupled receptors and tyrosine kinase receptors, but they are indicated to facilitate the degradation of TGF-beta receptors and therefore turnoff of TGF-beta signaling. This review summarizes current understanding of TGF-beta receptor endocytosis, the possible mechanisms underlying this process, and the role of endocytosis in modulation of TGF-beta signaling.}, author = {Chen, Y. G.}, citeulike-article-id = {3986671}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/cr.2008.315}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/cr2008315a}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19050695}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19050695}, doi = {10.1038/cr.2008.315}, issn = {1748-7838}, journal = {Cell research}, keywords = {clathrin, endocytosis, raft, tgfb, tgfbr}, month = {January}, number = {1}, pages = {58--70}, posted-at = {2009-01-31 04:25:04}, priority = {2}, publisher = {Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences}, title = {Endocytic regulation of TGF-beta signaling.}, url = {http://dx.doi.org/10.1038/cr.2008.315}, volume = {19}, year = {2009} }

TY - JOUR ID - citeulike:3986671 L3 - citeulike-article-id:3986671 N2 - Transforming growth factor-beta (TGF-beta) signaling is tightly regulated to ensure its proper physiological functions in different cells and tissues. Like other cell surface receptors, TGF-beta receptors are internalized into the cell, and this process plays an important regulatory role in TGF-beta signaling. It is well documented that TGF-beta receptors are endocytosed via clathrin-coated vesicles as TGF-beta endocytosis can be blocked by potassium depletion and the GTPase-deficient dynamin K44A mutant. TGF-beta receptors may also enter cells via cholesterol-rich membrane microdomain lipid rafts/caveolae and are found in caveolin-1-positive vesicles. Although receptor endocytosis is not essential for TGF-beta signaling, clathrin-mediated endocytosis has been shown to promote TGF-beta-induced Smad activation and transcriptional responses. Lipid rafts/caveolae are widely regarded as signaling centers for G protein-coupled receptors and tyrosine kinase receptors, but they are indicated to facilitate the degradation of TGF-beta receptors and therefore turnoff of TGF-beta signaling. This review summarizes current understanding of TGF-beta receptor endocytosis, the possible mechanisms underlying this process, and the role of endocytosis in modulation of TGF-beta signaling. IS - 1 JF - Cell research SN - 1748-7838 EP - 70 TI - Endocytic regulation of TGF-beta signaling. PB - Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences VL - 19 SP - 58 KW - clathrin KW - endocytosis KW - raft KW - tgfb KW - tgfbr AU - Chen, YG PY - 2009/01// UR - http://dx.doi.org/10.1038/cr.2008.315 ER -