Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Export

@article{citeulike:4135026, abstract = {Resistin is a recently discovered polypeptide that induces insulin resistance in rodents. While in rodents resistin is predominantly expressed in adipocytes, in humans peripheral blood mononuclear cells (PBMC) seem to a be a major source of resistin. In the present study, we show that in human PBMC resistin mRNA expression-determined by fluorescence-based real-time polymerase chain reaction-is strongly increased by the proinflammatory cytokines interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-alpha), and also by lipopolysaccharides (LPS), respectively, while no effect was found by interferon-gamma (IFN-gamma) or leptin. Our results suggest that in humans resistin may be a link in the well-known association between inflammation and insulin resistance.}, author = {Kaser, S. and Kaser, A. and Sandhofer, A. and Ebenbichler, C. F. and Tilg, H. and Patsch, J. R.}, citeulike-article-id = {4135026}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12951047}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12951047}, day = {19}, issn = {0006-291X}, journal = {Biochemical and biophysical research communications}, keywords = {cytokine, pbmc, resistin}, month = {September}, number = {2}, pages = {286--290}, posted-at = {2009-03-05 08:54:35}, priority = {2}, title = {Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12951047}, volume = {309}, year = {2003} }

TY - JOUR ID - citeulike:4135026 L3 - citeulike-article-id:4135026 N2 - Resistin is a recently discovered polypeptide that induces insulin resistance in rodents. While in rodents resistin is predominantly expressed in adipocytes, in humans peripheral blood mononuclear cells (PBMC) seem to a be a major source of resistin. In the present study, we show that in human PBMC resistin mRNA expression-determined by fluorescence-based real-time polymerase chain reaction-is strongly increased by the proinflammatory cytokines interleukin (IL)-1, IL-6, tumor necrosis factor alpha (TNF-alpha), and also by lipopolysaccharides (LPS), respectively, while no effect was found by interferon-gamma (IFN-gamma) or leptin. Our results suggest that in humans resistin may be a link in the well-known association between inflammation and insulin resistance. IS - 2 JF - Biochemical and biophysical research communications SN - 0006-291X EP - 290 TI - Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. VL - 309 SP - 286 KW - cytokine KW - pbmc KW - resistin AU - Kaser, S AU - Kaser, A AU - Sandhofer, A AU - Ebenbichler, CF AU - Tilg, H AU - Patsch, JR PY - 2003/09/19/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12951047 ER -