PGC-1alpha in aging and anti-aging interventions. Export

@article{citeulike:4608726, abstract = {Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction - a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process.}, author = {Anderson, Rozalyn and Prolla, Tomas}, citeulike-article-id = {4608726}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.bbagen.2009.04.005}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0304416509000907}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19371772}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19371772}, doi = {10.1016/j.bbagen.2009.04.005}, issn = {0006-3002}, journal = {Biochimica et biophysica acta}, keywords = {aging, pgc1}, month = {April}, posted-at = {2009-07-04 07:02:49}, priority = {2}, title = {PGC-1alpha in aging and anti-aging interventions.}, url = {http://dx.doi.org/10.1016/j.bbagen.2009.04.005}, year = {2009} }

TY - JOUR ID - citeulike:4608726 L3 - citeulike-article-id:4608726 N2 - Deregulation of mitochondrial function is a common feature in multiple aspects of aging. In addition to playing a role in aging-associated disease, decline in mitochondrial energy metabolism is likely to be important in the development of metabolic disease. Furthermore, altered mitochondrial function is a conserved feature in caloric restriction - a dietary intervention that delays aging in diverse species. The transcriptional co-activator PGC-1alpha is a critical regulator of mitochondrial energy metabolism and biogenesis. PGC-1alpha is uniquely poised as a potential target for correcting the effects of age on mitochondrial decline. We describe the cellular and tissue specific mechanisms of PGC-1alpha regulation and illustrate how these pathways may be involved in the aging process. JF - Biochimica et biophysica acta SN - 0006-3002 TI - PGC-1alpha in aging and anti-aging interventions. KW - aging KW - pgc1 AU - Anderson, Rozalyn AU - Prolla, Tomas PY - 2009/04/14/ UR - http://dx.doi.org/10.1016/j.bbagen.2009.04.005 ER -