The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Export

@article{citeulike:4629543, abstract = {Mitochondria are dynamic organelles that integrate environmental signals to regulate energy production, apoptosis and Ca(2+) homeostasis. Not surprisingly, mitochondrial dysfunction is associated with aging and the pathologies observed in age-related diseases. The vast majority of mitochondrial proteins are encoded in the nuclear genome, and so communication between the nucleus and mitochondria is essential for maintenance of appropriate mitochondrial function. Several proteins have emerged as major regulators of mitochondrial gene expression, capable of increasing transcription of mitochondrial genes in response to the physiological demands of the cell. In this review, we will focus on PGC-1alpha, SIRT1, AMPK and mTOR and discuss how these proteins regulate mitochondrial function and their potential involvement in aging, calorie restriction and age-related disease. We will also discuss the pathways through which mitochondria signal to the nucleus. Although such retrograde signaling is not well studied in mammals, there is growing evidence to suggest that it may be an important area for future aging research. Greater understanding of the mechanisms by which mitochondria and the nucleus communicate will facilitate efforts to slow or reverse the mitochondrial dysfunction that occurs during aging.}, author = {Finley, Lydia W. and Haigis, Marcia C.}, citeulike-article-id = {4629543}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.arr.2009.03.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1568163709000166}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19491041}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19491041}, day = {27}, doi = {10.1016/j.arr.2009.03.003}, issn = {1872-9649}, journal = {Ageing research reviews}, keywords = {aging, ampk, mt, mtor, pgc, sirt}, month = {July}, number = {3}, pages = {173--188}, posted-at = {2009-07-04 06:58:02}, priority = {2}, title = {The coordination of nuclear and mitochondrial communication during aging and calorie restriction.}, url = {http://dx.doi.org/10.1016/j.arr.2009.03.003}, volume = {8}, year = {2009} }

TY - JOUR ID - citeulike:4629543 L3 - citeulike-article-id:4629543 N2 - Mitochondria are dynamic organelles that integrate environmental signals to regulate energy production, apoptosis and Ca(2+) homeostasis. Not surprisingly, mitochondrial dysfunction is associated with aging and the pathologies observed in age-related diseases. The vast majority of mitochondrial proteins are encoded in the nuclear genome, and so communication between the nucleus and mitochondria is essential for maintenance of appropriate mitochondrial function. Several proteins have emerged as major regulators of mitochondrial gene expression, capable of increasing transcription of mitochondrial genes in response to the physiological demands of the cell. In this review, we will focus on PGC-1alpha, SIRT1, AMPK and mTOR and discuss how these proteins regulate mitochondrial function and their potential involvement in aging, calorie restriction and age-related disease. We will also discuss the pathways through which mitochondria signal to the nucleus. Although such retrograde signaling is not well studied in mammals, there is growing evidence to suggest that it may be an important area for future aging research. Greater understanding of the mechanisms by which mitochondria and the nucleus communicate will facilitate efforts to slow or reverse the mitochondrial dysfunction that occurs during aging. IS - 3 JF - Ageing research reviews SN - 1872-9649 EP - 188 TI - The coordination of nuclear and mitochondrial communication during aging and calorie restriction. VL - 8 SP - 173 KW - aging KW - ampk KW - mt KW - mtor KW - pgc KW - sirt AU - Finley, Lydia AU - Haigis, Marcia PY - 2009/07/27/ UR - http://dx.doi.org/10.1016/j.arr.2009.03.003 ER -