Long-lived Indy and calorie restriction interact to extend life span. Export

@article{citeulike:4790812, abstract = {Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR, the mechanism by which CR extends life span remains unclear. The Drosophila gene Indy (for I'm not dead yet), involved in the transport and storage of Krebs cycle intermediates in tissues important in fly metabolism, was proposed to regulate life span via an effect on metabolism that could overlap with CR. In this study, we report that CR down regulates Indy mRNA expression, and that CR and the level of Indy expression interact to affect longevity. Optimal life span extension is seen when Indy expression is decreased between 25 and 75\% of normal. Indy long-lived flies show several phenotypes that are shared by long-lived CR flies, including decreased insulin-like signaling, lipid storage, weight gain, and resistance to starvation as well as an increase in spontaneous physical activity. We conclude that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension.}, author = {Wang, Pei-Yu Y. and Neretti, Nicola and Whitaker, Rachel and Hosier, Suzanne and Chang, Chengyi and Lu, Daniel and Rogina, Blanka and Helfand, Stephen L.}, citeulike-article-id = {4790812}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0904115106}, citeulike-linkout-1 = {http://www.pnas.org/content/106/23/9262.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/106/23/9262.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19470468}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19470468}, day = {9}, doi = {10.1073/pnas.0904115106}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {aging, cr, indy}, month = {June}, number = {23}, pages = {9262--9267}, posted-at = {2009-11-10 02:08:47}, priority = {2}, title = {Long-lived Indy and calorie restriction interact to extend life span.}, url = {http://dx.doi.org/10.1073/pnas.0904115106}, volume = {106}, year = {2009} }

TY - JOUR ID - citeulike:4790812 L3 - citeulike-article-id:4790812 N2 - Calorie restriction (CR) improves health and extends life span in a variety of species. Despite many downstream molecules and physiological systems having been identified as being regulated by CR, the mechanism by which CR extends life span remains unclear. The Drosophila gene Indy (for I'm not dead yet), involved in the transport and storage of Krebs cycle intermediates in tissues important in fly metabolism, was proposed to regulate life span via an effect on metabolism that could overlap with CR. In this study, we report that CR down regulates Indy mRNA expression, and that CR and the level of Indy expression interact to affect longevity. Optimal life span extension is seen when Indy expression is decreased between 25 and 75% of normal. Indy long-lived flies show several phenotypes that are shared by long-lived CR flies, including decreased insulin-like signaling, lipid storage, weight gain, and resistance to starvation as well as an increase in spontaneous physical activity. We conclude that Indy and CR interact to affect longevity and that a decrease in Indy may induce a CR-like status that confers life span extension. IS - 23 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 EP - 9267 TI - Long-lived Indy and calorie restriction interact to extend life span. VL - 106 SP - 9262 KW - aging KW - cr KW - indy AU - Wang, Pei-Yu AU - Neretti, Nicola AU - Whitaker, Rachel AU - Hosier, Suzanne AU - Chang, Chengyi AU - Lu, Daniel AU - Rogina, Blanka AU - Helfand, Stephen PY - 2009/06/09/ UR - http://dx.doi.org/10.1073/pnas.0904115106 ER -