Increased microRNA activity in human cancers. Export

@article{citeulike:4952941, abstract = {MicroRNAs (miRNAs) are small regulatory RNAs that act by blocking the translation and increasing the degradation of target transcripts. MiRNAs play a critical role in many biological processes including development and differentiation and many studies have shown that major changes in miRNA levels occur in cancer. Since miRNAs degrade target messages, we used this property to develop a novel computational method aimed at determining the actual biological activity of miRNAs using variations in gene expression. Using the method described here, we quantified miRNA activity in papillary thyroid carcinoma and breast cancer, and found a strong and distinctive signal of increased global miRNA activity, embedded in the pertaining gene expression measurements. Interestingly, we found that in these two cancers, miRNA activity is globally increased, and is associated with a global downregulation of miRNA target genes. This downregulation of miRNA regulated genes is particularly noticeable for genes carrying multiple target sites for miRNAs. Among the miRNA-repressed genes, we found a significant enrichment of known tumor suppressors, thereby suggesting that the increased miRNA activity was indeed tumorigenic.}, author = {Israel, Ariel and Sharan, Roded and Ruppin, Eytan and Galun, Eithan}, citeulike-article-id = {4952941}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0006045}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19557174}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19557174}, day = {25}, doi = {10.1371/journal.pone.0006045}, issn = {1932-6203}, journal = {PloS one}, keywords = {activity, cancer, mirna}, month = {June}, number = {6}, pages = {e6045+}, posted-at = {2009-08-06 16:40:26}, priority = {2}, publisher = {Public Library of Science}, title = {Increased microRNA activity in human cancers.}, url = {http://dx.doi.org/10.1371/journal.pone.0006045}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:4952941 L3 - citeulike-article-id:4952941 N2 - MicroRNAs (miRNAs) are small regulatory RNAs that act by blocking the translation and increasing the degradation of target transcripts. MiRNAs play a critical role in many biological processes including development and differentiation and many studies have shown that major changes in miRNA levels occur in cancer. Since miRNAs degrade target messages, we used this property to develop a novel computational method aimed at determining the actual biological activity of miRNAs using variations in gene expression. Using the method described here, we quantified miRNA activity in papillary thyroid carcinoma and breast cancer, and found a strong and distinctive signal of increased global miRNA activity, embedded in the pertaining gene expression measurements. Interestingly, we found that in these two cancers, miRNA activity is globally increased, and is associated with a global downregulation of miRNA target genes. This downregulation of miRNA regulated genes is particularly noticeable for genes carrying multiple target sites for miRNAs. Among the miRNA-repressed genes, we found a significant enrichment of known tumor suppressors, thereby suggesting that the increased miRNA activity was indeed tumorigenic. IS - 6 JF - PloS one SN - 1932-6203 TI - Increased microRNA activity in human cancers. PB - Public Library of Science VL - 4 SP - e6045 KW - activity KW - cancer KW - mirna AU - Israel, Ariel AU - Sharan, Roded AU - Ruppin, Eytan AU - Galun, Eithan PY - 2009/06/25/ UR - http://dx.doi.org/10.1371/journal.pone.0006045 ER -