The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. Export

@article{citeulike:5006197, abstract = {Once considered as a mere by-product of respiration, mitochondrial generation of reactive oxygen species (ROS) has recently emerged as a genetically controlled phenomenon, involved in complex intracellular signal transduction cascades that directly regulate cell survival and death in responses to environmental stressors. These cascades are involved in the pathogenesis of several major age-related diseases, such as cancer and neurodegeneration, and also appear to somehow regulate the "normal" ageing process. The present short review summarizes recent discoveries on mitochondrial reactive oxygen species regulation by p53, a tumor suppressor protein and p66shc, a protein implicated in the life-span determination. It also outlines the emerging network whereby these molecules cross-talk with each other and with the mitochondrial antioxidant system, namely MnSOD (SOD2), another life-span determining protein, to regulate oxidative stress in the organelle. This molecular circuit, which comprises two genetic determinants of longevity and a major tumor suppressor gene, also provides a theoretical framework connecting senescence and cancer.}, author = {Pani, Giovambattista and Koch, Osvaldo Ra\`{u}l R. and Galeotti, Tommaso}, citeulike-article-id = {5006197}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.biocel.2008.10.011}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18992840}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18992840}, doi = {10.1016/j.biocel.2008.10.011}, issn = {1878-5875}, journal = {The international journal of biochemistry \& cell biology}, keywords = {mt, p53, ros, shc, sod}, month = {May}, number = {5}, pages = {1002--1005}, posted-at = {2009-06-29 05:24:04}, priority = {2}, title = {The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species.}, url = {http://dx.doi.org/10.1016/j.biocel.2008.10.011}, volume = {41}, year = {2009} }

TY - JOUR ID - citeulike:5006197 L3 - citeulike-article-id:5006197 N2 - Once considered as a mere by-product of respiration, mitochondrial generation of reactive oxygen species (ROS) has recently emerged as a genetically controlled phenomenon, involved in complex intracellular signal transduction cascades that directly regulate cell survival and death in responses to environmental stressors. These cascades are involved in the pathogenesis of several major age-related diseases, such as cancer and neurodegeneration, and also appear to somehow regulate the "normal" ageing process. The present short review summarizes recent discoveries on mitochondrial reactive oxygen species regulation by p53, a tumor suppressor protein and p66shc, a protein implicated in the life-span determination. It also outlines the emerging network whereby these molecules cross-talk with each other and with the mitochondrial antioxidant system, namely MnSOD (SOD2), another life-span determining protein, to regulate oxidative stress in the organelle. This molecular circuit, which comprises two genetic determinants of longevity and a major tumor suppressor gene, also provides a theoretical framework connecting senescence and cancer. IS - 5 JF - The international journal of biochemistry & cell biology SN - 1878-5875 EP - 1005 TI - The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. VL - 41 SP - 1002 KW - mt KW - p53 KW - ros KW - shc KW - sod AU - Pani, Giovambattista AU - Koch, Osvaldo Raùl AU - Galeotti, Tommaso PY - 2009/05// UR - http://dx.doi.org/10.1016/j.biocel.2008.10.011 ER -