Spatial signaling networks converge at the adaptor protein Shc. Export

@article{citeulike:5006281, abstract = {Endothelial cells, which are located at the interface between the blood and the vessel wall, respond dynamically to a variety of stimuli initiating signaling cascades that regulate cardiovascular development, physiology and pathology. These inputs include soluble factors that bind to their receptors, integrin-matrix interactions, cell-cell contacts and mechanical forces due to the flowing blood. While these stimuli can mediate unique downstream signals, it is well-accepted that signaling pathways are highly interwoven into complex signaling networks with several levels of cross-talk, integration and coordination. Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc.}, author = {Sweet, D. T. and Tzima, E.}, citeulike-article-id = {5006281}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19164921}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19164921}, day = {15}, issn = {1551-4005}, journal = {Cell cycle (Georgetown, Tex.)}, keywords = {endothelium, shc}, month = {January}, number = {2}, pages = {231--235}, posted-at = {2009-06-29 05:34:07}, priority = {2}, title = {Spatial signaling networks converge at the adaptor protein Shc.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19164921}, volume = {8}, year = {2009} }

TY - JOUR ID - citeulike:5006281 L3 - citeulike-article-id:5006281 N2 - Endothelial cells, which are located at the interface between the blood and the vessel wall, respond dynamically to a variety of stimuli initiating signaling cascades that regulate cardiovascular development, physiology and pathology. These inputs include soluble factors that bind to their receptors, integrin-matrix interactions, cell-cell contacts and mechanical forces due to the flowing blood. While these stimuli can mediate unique downstream signals, it is well-accepted that signaling pathways are highly interwoven into complex signaling networks with several levels of cross-talk, integration and coordination. Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc. IS - 2 JF - Cell cycle (Georgetown, Tex.) SN - 1551-4005 EP - 235 TI - Spatial signaling networks converge at the adaptor protein Shc. VL - 8 SP - 231 KW - endothelium KW - shc AU - Sweet, DT AU - Tzima, E PY - 2009/01/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/19164921 ER -