Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats. Export

@article{citeulike:5765240, abstract = {Up regulation of the transforming growth factor-beta 1 (TGF-beta1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from diabetic rats accumulate up to sixfold more extracellular adenosine than normal rats. Both decreased nucleoside uptake activity by the equilibrative nucleoside transporter 1 and increased AMP hydrolysis contribute to raise extracellular adenosine. Ex vivo assays indicate that activation of the low affinity adenosine A2B receptor subtype (A2BAR) mediates TGF-beta1 release from glomeruli of diabetic rats, a pathogenic event that could support progression of glomerulopathy when the bioavailability of adenosine is increased.}, author = {Roa, H. and Gajardo, C. and Troncoso, E. and Fuentealba, V. and Escudero, C. and Y\'{a}\~{n}ez, A. and Sobrevia, L. and Pastor-Anglada, M. and Quezada, C. and San Martin, R.}, citeulike-article-id = {5765240}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.febslet.2009.09.003}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0014579309006875}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19737558}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19737558}, day = {6}, doi = {10.1016/j.febslet.2009.09.003}, issn = {1873-3468}, journal = {FEBS letters}, keywords = {adenosine, dn, rat, tgfb}, month = {October}, number = {19}, pages = {3192--3198}, posted-at = {2009-10-03 15:56:43}, priority = {2}, title = {Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats.}, url = {http://dx.doi.org/10.1016/j.febslet.2009.09.003}, volume = {583}, year = {2009} }

TY - JOUR ID - citeulike:5765240 L3 - citeulike-article-id:5765240 N2 - Up regulation of the transforming growth factor-beta 1 (TGF-beta1) axis has been recognized as a pathogenic event for progression of glomerulosclerosis in diabetic nephropathy. We demonstrate that glomeruli isolated from diabetic rats accumulate up to sixfold more extracellular adenosine than normal rats. Both decreased nucleoside uptake activity by the equilibrative nucleoside transporter 1 and increased AMP hydrolysis contribute to raise extracellular adenosine. Ex vivo assays indicate that activation of the low affinity adenosine A2B receptor subtype (A2BAR) mediates TGF-beta1 release from glomeruli of diabetic rats, a pathogenic event that could support progression of glomerulopathy when the bioavailability of adenosine is increased. IS - 19 JF - FEBS letters SN - 1873-3468 EP - 3198 TI - Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats. VL - 583 SP - 3192 KW - adenosine KW - dn KW - rat KW - tgfb AU - Roa, H AU - Gajardo, C AU - Troncoso, E AU - Fuentealba, V AU - Escudero, C AU - Yáñez, A AU - Sobrevia, L AU - Pastor-Anglada, M AU - Quezada, C AU - San Martin, R PY - 2009/10/06/ UR - http://dx.doi.org/10.1016/j.febslet.2009.09.003 ER -