Design and statistical aspects of the African American Study of Kidney Disease and Hypertension (AASK). Export

@article{citeulike:5918607, abstract = {The African American Study of Kidney Disease and Hypertension (AASK) is a multicenter randomized clinical trial designed to test the effectiveness of three anti-hypertensive drug regimens and two levels of BP control on the progression of hypertensive kidney disease. Participants include African-American men and women aged 18 to 70 yr who have hypertensive kidney disease and GFR between 20 and 65 ml/min per 1.73 m(2). The three anti-hypertensive drug regimens include an angiotensin converting enzyme inhibitor (ramipril), a dihydropyridine calcium channel blocker (amlodipine) or a beta-blocker (metoprolol) as initial therapy. The BP control levels are a lower goal (mean arterial pressure, </=92 mmHg) and a usual goal (mean arterial pressure, 102 to 107 mmHg inclusive). The primary outcome is rate of change in renal function as measured by GFR, assessed by (125) I-iothalamate clearance. The main secondary patient outcome is a composite including the following events: (1) reduction in GFR by 50\%, (2) end-stage renal disease, or (3) death.}, author = {Gassman, Jennifer J. and Greene, Tom and Wright, Jackson T. and Agodoa, Lawrence and Bakris, George and Beck, Gerald J. and Douglas, Janice and Jamerson, Ken and Lewis, Julia and Kutner, Michael and Randall, Otelio S. and Wang, Shin-Ru R.}, citeulike-article-id = {5918607}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12819322}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12819322}, issn = {1046-6673}, journal = {Journal of the American Society of Nephrology : JASN}, keywords = {aask, gfr\_formula, rct, stats}, month = {July}, number = {7 Suppl 2}, posted-at = {2009-10-10 08:19:46}, priority = {2}, title = {Design and statistical aspects of the African American Study of Kidney Disease and Hypertension (AASK).}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12819322}, volume = {14}, year = {2003} }

TY - JOUR ID - citeulike:5918607 L3 - citeulike-article-id:5918607 N2 - The African American Study of Kidney Disease and Hypertension (AASK) is a multicenter randomized clinical trial designed to test the effectiveness of three anti-hypertensive drug regimens and two levels of BP control on the progression of hypertensive kidney disease. Participants include African-American men and women aged 18 to 70 yr who have hypertensive kidney disease and GFR between 20 and 65 ml/min per 1.73 m(2). The three anti-hypertensive drug regimens include an angiotensin converting enzyme inhibitor (ramipril), a dihydropyridine calcium channel blocker (amlodipine) or a beta-blocker (metoprolol) as initial therapy. The BP control levels are a lower goal (mean arterial pressure, </=92 mmHg) and a usual goal (mean arterial pressure, 102 to 107 mmHg inclusive). The primary outcome is rate of change in renal function as measured by GFR, assessed by (125) I-iothalamate clearance. The main secondary patient outcome is a composite including the following events: (1) reduction in GFR by 50%, (2) end-stage renal disease, or (3) death. IS - 7 Suppl 2 JF - Journal of the American Society of Nephrology : JASN SN - 1046-6673 TI - Design and statistical aspects of the African American Study of Kidney Disease and Hypertension (AASK). VL - 14 KW - aask KW - gfr_formula KW - rct KW - stats AU - Gassman, Jennifer AU - Greene, Tom AU - Wright, Jackson AU - Agodoa, Lawrence AU - Bakris, George AU - Beck, Gerald AU - Douglas, Janice AU - Jamerson, Ken AU - Lewis, Julia AU - Kutner, Michael AU - Randall, Otelio AU - Wang, Shin-Ru PY - 2003/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/12819322 ER -