Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. Export

@article{citeulike:5996483, abstract = {OBJECTIVES: We sought to investigate the relationship between increased central venous pressure (CVP), renal function, and mortality in a broad spectrum of cardiovascular patients. BACKGROUND: The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. The relative importance of increased CVP has not been addressed previously. METHODS: A total of 2,557 patients who underwent right heart catheterization in the University Medical Center Groningen, the Netherlands, between January 1, 1989, and December 31, 2006, were identified, and their data were extracted from electronic databases. Estimated glomerular filtration rate (eGFR) was assessed with the simplified modification of diet in renal disease formula. RESULTS: Mean age was 59 +/- 15 years, and 57\% were men. Mean eGFR was 65 +/- 24 ml/min/1.73 m(2), with a cardiac index of 2.9 +/- 0.8 l/min/m(2) and CVP of 5.9 +/- 4.3 mm Hg. We found that CVP was associated with cardiac index (r = -0.259, p < 0.0001) and eGFR (r = -0.147, p < 0.0001). Also, cardiac index was associated with eGFR (r = 0.123, p < 0.0001). In multivariate analysis CVP remained associated with eGFR (r = -0.108, p < 0.0001). In a median follow-up time of 10.7 years, 741 (29\%) patients died. We found that CVP was an independent predictor of reduced survival (hazard ratio: 1.03 per mm Hg increase, 95\% confidence interval: 1.01 to 1.05, p = 0.0032). CONCLUSIONS: Increased CVP is associated with impaired renal function and independently related to all-cause mortality in a broad spectrum of patients with cardiovascular disease.}, author = {Damman, Kevin and van Deursen, Vincent M. and Navis, Gerjan and Voors, Adriaan A. and van Veldhuisen, Dirk J. and Hillege, Hans L.}, citeulike-article-id = {5996483}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jacc.2008.08.080}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19215832}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19215832}, day = {17}, doi = {10.1016/j.jacc.2008.08.080}, issn = {1558-3597}, journal = {Journal of the American College of Cardiology}, keywords = {cardiorenal, chf}, month = {February}, number = {7}, pages = {582--588}, posted-at = {2009-10-23 05:06:00}, priority = {2}, title = {Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease.}, url = {http://dx.doi.org/10.1016/j.jacc.2008.08.080}, volume = {53}, year = {2009} }

TY - JOUR ID - citeulike:5996483 L3 - citeulike-article-id:5996483 N2 - OBJECTIVES: We sought to investigate the relationship between increased central venous pressure (CVP), renal function, and mortality in a broad spectrum of cardiovascular patients. BACKGROUND: The pathophysiology of impaired renal function in cardiovascular disease is multifactorial. The relative importance of increased CVP has not been addressed previously. METHODS: A total of 2,557 patients who underwent right heart catheterization in the University Medical Center Groningen, the Netherlands, between January 1, 1989, and December 31, 2006, were identified, and their data were extracted from electronic databases. Estimated glomerular filtration rate (eGFR) was assessed with the simplified modification of diet in renal disease formula. RESULTS: Mean age was 59 +/- 15 years, and 57% were men. Mean eGFR was 65 +/- 24 ml/min/1.73 m(2), with a cardiac index of 2.9 +/- 0.8 l/min/m(2) and CVP of 5.9 +/- 4.3 mm Hg. We found that CVP was associated with cardiac index (r = -0.259, p < 0.0001) and eGFR (r = -0.147, p < 0.0001). Also, cardiac index was associated with eGFR (r = 0.123, p < 0.0001). In multivariate analysis CVP remained associated with eGFR (r = -0.108, p < 0.0001). In a median follow-up time of 10.7 years, 741 (29%) patients died. We found that CVP was an independent predictor of reduced survival (hazard ratio: 1.03 per mm Hg increase, 95% confidence interval: 1.01 to 1.05, p = 0.0032). CONCLUSIONS: Increased CVP is associated with impaired renal function and independently related to all-cause mortality in a broad spectrum of patients with cardiovascular disease. IS - 7 JF - Journal of the American College of Cardiology SN - 1558-3597 EP - 588 TI - Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. VL - 53 SP - 582 KW - cardiorenal KW - chf AU - Damman, Kevin AU - van Deursen, Vincent AU - Navis, Gerjan AU - Voors, Adriaan AU - van Veldhuisen, Dirk AU - Hillege, Hans PY - 2009/02/17/ UR - http://dx.doi.org/10.1016/j.jacc.2008.08.080 ER -