Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia Export

@article{citeulike:6031218, abstract = {10.1074/jbc.M800102200 Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.}, author = {Zhang, Huafeng and Bosch-Marce, Marta and Shimoda, Larissa A. and Tan, Yee S. and Baek, Jin H. and Wesley, Jacob B. and Gonzalez, Frank J. and Semenza, Gregg L.}, citeulike-article-id = {6031218}, citeulike-linkout-0 = {http://dx.doi.org/10.1074/jbc.M800102200}, citeulike-linkout-1 = {http://www.jbc.org/content/283/16/10892.abstract}, citeulike-linkout-2 = {http://www.jbc.org/content/283/16/10892.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/18281291}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=18281291}, day = {18}, doi = {10.1074/jbc.M800102200}, journal = {Journal of Biological Chemistry}, keywords = {autophagy, hif, mt}, month = {April}, number = {16}, pages = {10892--10903}, posted-at = {2009-10-29 05:24:13}, priority = {2}, title = {Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia}, url = {http://dx.doi.org/10.1074/jbc.M800102200}, volume = {283}, year = {2008} }

TY - JOUR ID - citeulike:6031218 L3 - citeulike-article-id:6031218 N2 - 10.1074/jbc.M800102200 Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death. IS - 16 JF - Journal of Biological Chemistry EP - 10903 TI - Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia VL - 283 SP - 10892 KW - autophagy KW - hif KW - mt AU - Zhang, Huafeng AU - Bosch-Marce, Marta AU - Shimoda, Larissa AU - Tan, Yee AU - Baek, Jin AU - Wesley, Jacob AU - Gonzalez, Frank AU - Semenza, Gregg PY - 2008/04/18/ UR - http://dx.doi.org/10.1074/jbc.M800102200 ER -