Pharmacological rationale for antibiotic treatment of intra-abdominal infections. Export

@article{citeulike:6058245, abstract = {The pharmacodynamic and pharmacokinetic (PK/PD) characteristics of antimicrobial agents are the two fundamental pharmacological components which provide a rationale for choosing therapy for intra-abdominal infections, especially when they are serious. It is well known which of the important PK/PD parameters can potentiate therapeutic efficacy. Antimicrobial agents can be subdivided into categories based on whether their activity depends on concentration or exposure time. Therefore, a correct dosing regimen for the time-dependent molecules (i.e. beta-lactams, linezolid, tigecycline) should prolong the maximum exposure time to maintain serum levels over the minimum inhibitory concentration (MIC). The concentration-dependent molecules, on the other hand, which include aminoglycosides and fluoroquinolones, should be administered to reach maximum concentrations, since they are bactericidal in direct proportion to their concentrations and possess a prolonged post-antibiotic effect.}, author = {Mazzei, T. and Novelli, A.}, citeulike-article-id = {6058245}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/19622447}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=19622447}, issn = {1973-9478}, journal = {Journal of chemotherapy (Florence, Italy)}, keywords = {antibiotics, gi}, month = {July}, pages = {19--29}, posted-at = {2009-11-03 04:55:48}, priority = {2}, title = {Pharmacological rationale for antibiotic treatment of intra-abdominal infections.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/19622447}, volume = {21 Suppl 1}, year = {2009} }

TY - JOUR ID - citeulike:6058245 L3 - citeulike-article-id:6058245 N2 - The pharmacodynamic and pharmacokinetic (PK/PD) characteristics of antimicrobial agents are the two fundamental pharmacological components which provide a rationale for choosing therapy for intra-abdominal infections, especially when they are serious. It is well known which of the important PK/PD parameters can potentiate therapeutic efficacy. Antimicrobial agents can be subdivided into categories based on whether their activity depends on concentration or exposure time. Therefore, a correct dosing regimen for the time-dependent molecules (i.e. beta-lactams, linezolid, tigecycline) should prolong the maximum exposure time to maintain serum levels over the minimum inhibitory concentration (MIC). The concentration-dependent molecules, on the other hand, which include aminoglycosides and fluoroquinolones, should be administered to reach maximum concentrations, since they are bactericidal in direct proportion to their concentrations and possess a prolonged post-antibiotic effect. JF - Journal of chemotherapy (Florence, Italy) SN - 1973-9478 EP - 29 TI - Pharmacological rationale for antibiotic treatment of intra-abdominal infections. VL - 21 Suppl 1 SP - 19 KW - antibiotics KW - gi AU - Mazzei, T AU - Novelli, A PY - 2009/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/19622447 ER -