Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal prorenin/renin receptor expression. Export

@article{citeulike:6066294, abstract = {Activation of prorenin/renin receptor [(P)RR] mediates non-enzymatic pathway for the physiological function of prorenin/renin. It also plays a role in the pathogenesis of diabetic nephropathy. However, the mechanisms of regulating (P)RR expression are only partially understood. In the present study, we examine the change of (P)RR under hyperglycemic conditions in the kidneys of streptozotocin (STZ)-induced diabetic (DM) rats and cultured rat renal glomerular mesangial cells (MCs). The (P)RR mRNA level was significantly lower in the kidney of (DM) rats than that of untreated control animals, meanwhile the plasma and renal angiotensin II (Ang II) levels and Ang II type 2 receptor (AT(2)R) mRNA level, but not Ang II type 1 receptor (AT(1)R) mRNA level were increased in (DM) rats. In cultured MCs, Ang II reduced the (P)RR expression and this inhibitory effect was blocked by the AT(2)R antagonist, PD123319, but not the AT(1)R antagonist, losartan. The AT(2)R agonist CGP42112A produced a similar effect as Ang II. Exposure to high glucose (30mM) resulted in a decrease in the (P)RR expression. PD123319, but not losartan, reversed high glucose induced (P)RR expression reduction. The present results indicate that activation of AT(2)R, but not AT(1)R, is most likely responsible for the reduced (P)RR expression in response to Ang II and high glucose in glomerular MCs and the renal tissue of STZ-treated rats.}, author = {He, Ming and Zhang, Lin and Shao, Ying and Xue, Hong and Zhou, Li and Wang, Xiao-Fang F. and Yu, Chen and Yao, Tai and Lu, Li-Min M.}, citeulike-article-id = {6066294}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.mce.2009.10.008}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0303720709005528}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19879325}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19879325}, day = {29}, doi = {10.1016/j.mce.2009.10.008}, issn = {1872-8057}, journal = {Molecular and cellular endocrinology}, keywords = {at2, dn, hg, mc, rat, renin}, month = {October}, posted-at = {2009-11-04 04:33:51}, priority = {2}, title = {Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal prorenin/renin receptor expression.}, url = {http://dx.doi.org/10.1016/j.mce.2009.10.008}, year = {2009} }

TY - JOUR ID - citeulike:6066294 L3 - citeulike-article-id:6066294 N2 - Activation of prorenin/renin receptor [(P)RR] mediates non-enzymatic pathway for the physiological function of prorenin/renin. It also plays a role in the pathogenesis of diabetic nephropathy. However, the mechanisms of regulating (P)RR expression are only partially understood. In the present study, we examine the change of (P)RR under hyperglycemic conditions in the kidneys of streptozotocin (STZ)-induced diabetic (DM) rats and cultured rat renal glomerular mesangial cells (MCs). The (P)RR mRNA level was significantly lower in the kidney of (DM) rats than that of untreated control animals, meanwhile the plasma and renal angiotensin II (Ang II) levels and Ang II type 2 receptor (AT(2)R) mRNA level, but not Ang II type 1 receptor (AT(1)R) mRNA level were increased in (DM) rats. In cultured MCs, Ang II reduced the (P)RR expression and this inhibitory effect was blocked by the AT(2)R antagonist, PD123319, but not the AT(1)R antagonist, losartan. The AT(2)R agonist CGP42112A produced a similar effect as Ang II. Exposure to high glucose (30mM) resulted in a decrease in the (P)RR expression. PD123319, but not losartan, reversed high glucose induced (P)RR expression reduction. The present results indicate that activation of AT(2)R, but not AT(1)R, is most likely responsible for the reduced (P)RR expression in response to Ang II and high glucose in glomerular MCs and the renal tissue of STZ-treated rats. JF - Molecular and cellular endocrinology SN - 1872-8057 TI - Angiotensin II type 2 receptor mediated angiotensin II and high glucose induced decrease in renal prorenin/renin receptor expression. KW - at2 KW - dn KW - hg KW - mc KW - rat KW - renin AU - He, Ming AU - Zhang, Lin AU - Shao, Ying AU - Xue, Hong AU - Zhou, Li AU - Wang, Xiao-Fang AU - Yu, Chen AU - Yao, Tai AU - Lu, Li-Min PY - 2009/10/29/ UR - http://dx.doi.org/10.1016/j.mce.2009.10.008 ER -