Nucleic acid biosensors for environmental pollution monitoring. Export

@article{citeulike:6072685, abstract = {Nucleic acid-based biosensors are finding increasing use for the detection of environmental pollution and toxicity. A biosensor is defined as a compact analytical device incorporating a biological or biologically-derived sensing element either integrated within or intimately associated with a physicochemical transducer. A nucleic acid-based biosensor employs as the sensing element an oligonucleotide, with a known sequence of bases, or a complex structure of DNA or RNA. Nucleic acid biosensors can be used to detect DNA/RNA fragments or either biological or chemical species. In the first application, DNA/RNA is the analyte and it is detected through the hybridization reaction (this kind of biosensor is also called a genosensor). In the second application, DNA/RNA plays the role of the receptor of specific biological and/or chemical species, such as target proteins, pollutants or drugs. Recent advances in the development and applications of nucleic acid-based biosensors for environmental application are reviewed in this article with special emphasis on functional nucleic acid elements (aptamers, DNAzymes, aptazymes) and lab-on-a-chip technology.}, author = {Palchetti, Ilaria and Mascini, Marco}, citeulike-article-id = {6072685}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/b802920m}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18575633}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18575633}, doi = {10.1039/b802920m}, issn = {1364-5528}, journal = {The Analyst}, keywords = {biosensor}, month = {July}, number = {7}, pages = {846--854}, posted-at = {2009-11-05 08:54:10}, priority = {2}, title = {Nucleic acid biosensors for environmental pollution monitoring.}, url = {http://dx.doi.org/10.1039/b802920m}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:6072685 L3 - citeulike-article-id:6072685 N2 - Nucleic acid-based biosensors are finding increasing use for the detection of environmental pollution and toxicity. A biosensor is defined as a compact analytical device incorporating a biological or biologically-derived sensing element either integrated within or intimately associated with a physicochemical transducer. A nucleic acid-based biosensor employs as the sensing element an oligonucleotide, with a known sequence of bases, or a complex structure of DNA or RNA. Nucleic acid biosensors can be used to detect DNA/RNA fragments or either biological or chemical species. In the first application, DNA/RNA is the analyte and it is detected through the hybridization reaction (this kind of biosensor is also called a genosensor). In the second application, DNA/RNA plays the role of the receptor of specific biological and/or chemical species, such as target proteins, pollutants or drugs. Recent advances in the development and applications of nucleic acid-based biosensors for environmental application are reviewed in this article with special emphasis on functional nucleic acid elements (aptamers, DNAzymes, aptazymes) and lab-on-a-chip technology. IS - 7 JF - The Analyst SN - 1364-5528 EP - 854 TI - Nucleic acid biosensors for environmental pollution monitoring. VL - 133 SP - 846 KW - biosensor AU - Palchetti, Ilaria AU - Mascini, Marco PY - 2008/07// UR - http://dx.doi.org/10.1039/b802920m ER -