Receptor tyrosine kinase signaling: a view from quantitative proteomics Export

@article{citeulike:6087045, abstract = {Growth factor receptor signaling via receptor tyrosine kinases (RTKs) is one of the basic cellular communication principals found in all metazoans. Extracellular signals are transferred via membrane spanning receptors into the cytoplasm, reversible tyrosine phosphorylation being the hallmark of all RTKs. In recent years proteomic approaches have yielded detailed descriptions of cellular signaling events. Quantitative proteomics is able to characterize the exact position and strength of post-translational modifications (PTMs) providing essential information for understanding the molecular basis of signal transduction. Numerous new post-translational modification sites have been identified by quantitative mass spectrometry-based proteomics. In addition, plentiful new players in signal transduction have been identified underlining the complexity and the modular architecture of most signaling networks. In this review, we outline the principles of signal transduction via RTKs and highlight some of the new insights obtained from proteomic approaches such as protein microarrays and quantitative mass spectrometry.}, author = {Dengjel, Joern and Kratchmarova, Irina and Blagoev, Blagoy}, citeulike-article-id = {6087045}, citeulike-linkout-0 = {http://dx.doi.org/10.1039/b909534a}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19756300}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19756300}, citeulike-linkout-3 = {http://www.rsc.org/Publishing/Journals/article.asp?doi=b909534a}, doi = {10.1039/b909534a}, issn = {1742-2051}, journal = {Mol. BioSyst.}, keywords = {egfr, proteomics, rtk}, month = {October}, number = {10}, pages = {1112--1121}, posted-at = {2009-11-09 04:49:11}, priority = {2}, publisher = {The Royal Society of Chemistry}, title = {Receptor tyrosine kinase signaling: a view from quantitative proteomics}, url = {http://dx.doi.org/10.1039/b909534a}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:6087045 L3 - citeulike-article-id:6087045 N2 - Growth factor receptor signaling via receptor tyrosine kinases (RTKs) is one of the basic cellular communication principals found in all metazoans. Extracellular signals are transferred via membrane spanning receptors into the cytoplasm, reversible tyrosine phosphorylation being the hallmark of all RTKs. In recent years proteomic approaches have yielded detailed descriptions of cellular signaling events. Quantitative proteomics is able to characterize the exact position and strength of post-translational modifications (PTMs) providing essential information for understanding the molecular basis of signal transduction. Numerous new post-translational modification sites have been identified by quantitative mass spectrometry-based proteomics. In addition, plentiful new players in signal transduction have been identified underlining the complexity and the modular architecture of most signaling networks. In this review, we outline the principles of signal transduction via RTKs and highlight some of the new insights obtained from proteomic approaches such as protein microarrays and quantitative mass spectrometry. IS - 10 JF - Mol. BioSyst. SN - 1742-2051 EP - 1121 TI - Receptor tyrosine kinase signaling: a view from quantitative proteomics PB - The Royal Society of Chemistry VL - 5 SP - 1112 KW - egfr KW - proteomics KW - rtk AU - Dengjel, Joern AU - Kratchmarova, Irina AU - Blagoev, Blagoy PY - 2009/10// UR - http://dx.doi.org/10.1039/b909534a ER -