The podocyte in diabetic kidney disease. Export

@article{citeulike:6092489, abstract = {Approaching epidemic levels, diabetic kidney disease (DKD) is now the leading cause of end-stage renal disease (ESRD). Microalbuminuria is an early clinical marker of DKD that results from damage to the glomerular filtration barrier at the level of the highly differentiated glomerular podocyte cells. Injury to these epithelial cells, podocytopathies, includes cellular hypertrophy, foot process effacement, detachment from the glomerular basement membrane, and apoptosis. Here we review the role of a number of recently identified factors that contribute to podocytopathies in DKD. These factors include members of the renin-angiotensin system (RAS), including angiotensin-converting enzyme (ACE) types 1 and 2, prorenin and its receptor, reactive oxygen species (ROS), prostanoids, peroxisome proliferator-activated receptors (PPAR), advanced glycation end-products (AGEs) and their receptors (RAGE), adiponectin, and microRNAs. As the number of therapeutic options that slow, but do not halt, the progression of DKD to ESRD remains limited, a more comprehensive understanding of the signaling events that contribute to this increasingly prevalent disease may identify novel avenues for treatment and prevention.}, author = {Stitt-Cavanagh, Erin and MacLeod, Laura and Kennedy, Chris}, citeulike-article-id = {6092489}, citeulike-linkout-0 = {http://dx.doi.org/10.1100/tsw.2009.133}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19838599}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19838599}, doi = {10.1100/tsw.2009.133}, issn = {1537-744X}, journal = {TheScientificWorldJournal}, keywords = {dn, podocyte}, pages = {1127--1139}, posted-at = {2009-11-10 09:38:36}, priority = {2}, title = {The podocyte in diabetic kidney disease.}, url = {http://dx.doi.org/10.1100/tsw.2009.133}, volume = {9}, year = {2009} }

TY - JOUR ID - citeulike:6092489 L3 - citeulike-article-id:6092489 N2 - Approaching epidemic levels, diabetic kidney disease (DKD) is now the leading cause of end-stage renal disease (ESRD). Microalbuminuria is an early clinical marker of DKD that results from damage to the glomerular filtration barrier at the level of the highly differentiated glomerular podocyte cells. Injury to these epithelial cells, podocytopathies, includes cellular hypertrophy, foot process effacement, detachment from the glomerular basement membrane, and apoptosis. Here we review the role of a number of recently identified factors that contribute to podocytopathies in DKD. These factors include members of the renin-angiotensin system (RAS), including angiotensin-converting enzyme (ACE) types 1 and 2, prorenin and its receptor, reactive oxygen species (ROS), prostanoids, peroxisome proliferator-activated receptors (PPAR), advanced glycation end-products (AGEs) and their receptors (RAGE), adiponectin, and microRNAs. As the number of therapeutic options that slow, but do not halt, the progression of DKD to ESRD remains limited, a more comprehensive understanding of the signaling events that contribute to this increasingly prevalent disease may identify novel avenues for treatment and prevention. JF - TheScientificWorldJournal SN - 1537-744X EP - 1139 TI - The podocyte in diabetic kidney disease. VL - 9 SP - 1127 KW - dn KW - podocyte AU - Stitt-Cavanagh, Erin AU - MacLeod, Laura AU - Kennedy, Chris PY - 2009/// UR - http://dx.doi.org/10.1100/tsw.2009.133 ER -