Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. Export

@article{citeulike:6096908, abstract = {The cyclic adenosine monophosphate-dependent protein kinase A (PKA) pathway helps regulate both cell growth and division, and triglyceride storage and metabolism in response to nutrient status. Studies in yeast show that disruption of this pathway promotes longevity in a manner similar to caloric restriction. Because PKA is highly conserved, it can be studied in mammalian systems. This report describes the metabolic phenotype of mice lacking the PKA catalytic subunit Cbeta. We confirmed that Cbeta has high levels of expression in the brain but also showed moderate levels in liver. Cbeta-null animals had reduced basal PKA activity while appearing overtly normal when fed standard rodent chow. However, the absence of Cbeta protected mice from diet-induced obesity, steatosis, dyslipoproteinemia, and insulin resistance, without any differences in caloric intake or locomotor activity. These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance.}, author = {Enns, Linda C. and Morton, John F. and Mangalindan, Ruby Sue S. and McKnight, G. Stanley and Schwartz, Michael W. and Kaeberlein, Matt R. and Kennedy, Brian K. and Rabinovitch, Peter S. and Ladiges, Warren C.}, citeulike-article-id = {6096908}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/gerona/glp133}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19776218}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19776218}, doi = {10.1093/gerona/glp133}, issn = {1758-535X}, journal = {The journals of gerontology. Series A, Biological sciences and medical sciences}, keywords = {aging, ko, mouse, obesity, pka}, month = {December}, number = {12}, pages = {1221--1231}, posted-at = {2009-11-11 06:08:58}, priority = {2}, title = {Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.}, url = {http://dx.doi.org/10.1093/gerona/glp133}, volume = {64}, year = {2009} }

TY - JOUR ID - citeulike:6096908 L3 - citeulike-article-id:6096908 N2 - The cyclic adenosine monophosphate-dependent protein kinase A (PKA) pathway helps regulate both cell growth and division, and triglyceride storage and metabolism in response to nutrient status. Studies in yeast show that disruption of this pathway promotes longevity in a manner similar to caloric restriction. Because PKA is highly conserved, it can be studied in mammalian systems. This report describes the metabolic phenotype of mice lacking the PKA catalytic subunit Cbeta. We confirmed that Cbeta has high levels of expression in the brain but also showed moderate levels in liver. Cbeta-null animals had reduced basal PKA activity while appearing overtly normal when fed standard rodent chow. However, the absence of Cbeta protected mice from diet-induced obesity, steatosis, dyslipoproteinemia, and insulin resistance, without any differences in caloric intake or locomotor activity. These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance. IS - 12 JF - The journals of gerontology. Series A, Biological sciences and medical sciences SN - 1758-535X EP - 1231 TI - Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. VL - 64 SP - 1221 KW - aging KW - ko KW - mouse KW - obesity KW - pka AU - Enns, Linda AU - Morton, John AU - Mangalindan, Ruby Sue AU - McKnight, Stanley AU - Schwartz, Michael AU - Kaeberlein, Matt AU - Kennedy, Brian AU - Rabinovitch, Peter AU - Ladiges, Warren PY - 2009/12// UR - http://dx.doi.org/10.1093/gerona/glp133 ER -