Relative rates of gene fusion and fission in multi-domain proteins. Export

@article{citeulike:1983171, abstract = {During evolution genes can produce more complex proteins by gene fusion or less complex proteins by gene fission. Considering proteins from 131 completely sequenced genomes from all three kingdoms of life, we identified 2869 groups of multi-domain proteins as a single protein in certain organisms and as two or more smaller proteins with equivalent domain architectures in other organisms. We found that fusion events are approximately four times more common than fission events, and we established that, in most cases, any particular fusion or fission event only occurred once during the course of evolution.}, address = {MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK, CB2 2QH. skk@mrc-lmb.cam.ac.uk}, author = {Kummerfeld, S. K. and Teichmann, S. A.}, citeulike-article-id = {1983171}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2004.11.007}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952504003099}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/15680510}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=15680510}, citeulike-linkout-4 = {http://www.sciencedirect.com/science/article/B6TCY-4DW36KS-1/2/0901de2eee69139665ec134582e923b6}, doi = {10.1016/j.tig.2004.11.007}, issn = {0168-9525}, journal = {Trends Genet}, keywords = {gene-fusion-fission}, month = {January}, number = {1}, pages = {25--30}, posted-at = {2008-08-21 21:50:26}, priority = {2}, title = {Relative rates of gene fusion and fission in multi-domain proteins.}, url = {http://dx.doi.org/10.1016/j.tig.2004.11.007}, volume = {21}, year = {2005} }

TY - JOUR ID - citeulike:1983171 L3 - citeulike-article-id:1983171 N2 - During evolution genes can produce more complex proteins by gene fusion or less complex proteins by gene fission. Considering proteins from 131 completely sequenced genomes from all three kingdoms of life, we identified 2869 groups of multi-domain proteins as a single protein in certain organisms and as two or more smaller proteins with equivalent domain architectures in other organisms. We found that fusion events are approximately four times more common than fission events, and we established that, in most cases, any particular fusion or fission event only occurred once during the course of evolution. IS - 1 JF - Trends Genet SN - 0168-9525 AD - MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK, CB2 2QH. skk@mrc-lmb.cam.ac.uk EP - 30 TI - Relative rates of gene fusion and fission in multi-domain proteins. VL - 21 SP - 25 KW - gene-fusion-fission AU - Kummerfeld, SK AU - Teichmann, SA PY - 2005/01// UR - http://dx.doi.org/10.1016/j.tig.2004.11.007 ER -