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Approximation Algorithms for Protein Folding Prediction (short)In SODA: {ACM}-{SIAM} Symposium on Discrete Algorithms (A Conference on Theoretical and Experimental Analysis of Discrete Algorithms) (1999)
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AbstractWe present a new polynomial-time algorithm for the protein folding problem in the two-dimensional HP model introduced by Dill [1], which has been recently proved to be NP-hard [2]. The model abstracts one of the dominant forces of protein folding: the hydrophobic-hydrophilic interaction. Thus, proteins are modeled as binary strings on the alphabet fH, Pg, representing chains of hydrophobic and hydrophilic monomers. The problem is to find, given a string s, the two-dimensional structure that...
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