The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis Export

@article{setlowPNAS1974, abstract = {DNA is taken as the target for skin cancer induced by ultraviolet light, and the known data on the sensitivity of DNA as a function of wavelength are summarized. The sun's spectrum at the surface of the earth and the DNA action spectrum are used to calculate the carcinogenic effectiveness as a function of wavelength. The most effective wavelengths at 30°N latitude are <305 nm, and a 1\% change in atmospheric ozone results in a 2\% change in the effective dose of ultraviolet light. Since both the basic biological and physical data are reasonably precise, the major requirement for a quantitative evaluation of the dose response relation for ultraviolet-induced skin cancer in man is better epidemiological data to compare with data from animal models.}, author = {Setlow, R. B.}, citeulike-article-id = {3477733}, citeulike-linkout-0 = {http://www.pnas.org/content/71/9/3363.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/71/9/3363.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/4530308}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=4530308}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {actionspectra, cancer, dna-damage, health, skin}, number = {9}, pages = {3363--3366}, posted-at = {2008-11-04 07:17:35}, priority = {0}, title = {The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis}, url = {http://www.pnas.org/content/71/9/3363.abstract}, volume = {71}, year = {1974} }

TY - JOUR ID - setlowPNAS1974 L3 - citeulike-article-id:3477733 N2 - DNA is taken as the target for skin cancer induced by ultraviolet light, and the known data on the sensitivity of DNA as a function of wavelength are summarized. The sun's spectrum at the surface of the earth and the DNA action spectrum are used to calculate the carcinogenic effectiveness as a function of wavelength. The most effective wavelengths at 30°N latitude are <305 nm, and a 1% change in atmospheric ozone results in a 2% change in the effective dose of ultraviolet light. Since both the basic biological and physical data are reasonably precise, the major requirement for a quantitative evaluation of the dose response relation for ultraviolet-induced skin cancer in man is better epidemiological data to compare with data from animal models. IS - 9 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 3366 TI - The Wavelengths in Sunlight Effective in Producing Skin Cancer: A Theoretical Analysis VL - 71 SP - 3363 KW - actionspectra KW - cancer KW - dna-damage KW - health KW - skin AU - Setlow, RB PY - 1974/// UR - http://www.pnas.org/content/71/9/3363.abstract ER -