Prediction of microRNA targets.

@article{maziere07, abstract = {Recently, microRNAs (miRNAs) have been shown to be important regulators of genes in many organisms and have already been implicated in a growing number of diseases. MiRNAs are short (21-23 nucleotides) RNAs that bind to the 3' untranslated regions of target genes. This binding event causes translational repression of the target gene and, evidence now suggests, also stimulates rapid degradation of the target transcript. miRNAs represent a new species of regulator, controlling the levels of potentially large numbers of proteins, many of which might be important drug targets. The expression of miRNAs shows that they are highly differentially expressed, with specific miRNAs active in certain tissues at certain times. In many cancers, miRNA expression is significantly altered, and this has been shown to be a useful diagnostic tool. Several computational approaches have been developed for the prediction of miRNA targets.}, address = {Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.}, author = {Mazi\`{e}re, P. and Enright, A. J. }, citeulike-article-id = {1342108}, doi = {http://dx.doi.org/10.1016/j.drudis.2007.04.002}, issn = {1359-6446}, journal = {Drug Discovery Today}, keywords = {microrna, microrna\_target\_prediction, review}, month = {April}, number = {11-12}, pages = {452--458}, posted-at = {2008-05-08 16:54:29}, priority = {3}, publisher = {Springer}, title = {Prediction of microRNA targets.}, url = {http://dx.doi.org/10.1016/j.drudis.2007.04.002}, volume = {12}, year = {2007} }

TY - JOUR ID - maziere07 L3 - citeulike-article-id:1342108 TI - Prediction of microRNA targets. JF - Drug Discovery Today VL - 12 IS - 11-12 SP - 452 EP - 458 AD - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. PB - Springer SN - 1359-6446 N2 - Recently, microRNAs (miRNAs) have been shown to be important regulators of genes in many organisms and have already been implicated in a growing number of diseases. MiRNAs are short (21-23 nucleotides) RNAs that bind to the 3' untranslated regions of target genes. This binding event causes translational repression of the target gene and, evidence now suggests, also stimulates rapid degradation of the target transcript. miRNAs represent a new species of regulator, controlling the levels of potentially large numbers of proteins, many of which might be important drug targets. The expression of miRNAs shows that they are highly differentially expressed, with specific miRNAs active in certain tissues at certain times. In many cancers, miRNA expression is significantly altered, and this has been shown to be a useful diagnostic tool. Several computational approaches have been developed for the prediction of miRNA targets. KW - microrna KW - microrna_target_prediction KW - review AU - Mazière, P AU - Enright, AJ PY - 2007/04/26/ UR - http://dx.doi.org/10.1016/j.drudis.2007.04.002 ER -