The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions

@article{citeulike:2846899, abstract = {Summary We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered presynaptic ACh secretion, suggesting that MEF-2 activity in muscles controls a retrograde signal. The effect of the MEF-2-dependent retrograde signal on secretion is mediated by the synaptic vesicle protein RAB-3. Finally, acute activation of levamisole-sensitive nAChRs stimulates MEF-2-dependent transcriptional responses and induces the MEF-2-dependent retrograde signal. We propose that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function.}, author = {Simon, David J. and Madison, Jon M. and Conery, Annie L. and Thompson-Peer, Katherine L. and Soskis, Michael and Ruvkun, Gary B. and Kaplan, Joshua M. and Kim, John K. }, citeulike-article-id = {2846899}, doi = {10.1016/j.cell.2008.04.035}, journal = {Cell}, keywords = {microrna}, month = {May}, number = {5}, pages = {903--915}, posted-at = {2008-05-30 10:43:49}, priority = {2}, title = {The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions}, url = {http://dx.doi.org/10.1016/j.cell.2008.04.035}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:2846899 L3 - citeulike-article-id:2846899 TI - The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions JF - Cell VL - 133 IS - 5 SP - 903 EP - 915 N2 - Summary We show that miR-1, a conserved muscle-specific microRNA, regulates aspects of both pre- and postsynaptic function at C. elegans neuromuscular junctions. miR-1 regulates the expression level of two nicotinic acetylcholine receptor (nAChR) subunits (UNC-29 and UNC-63), thereby altering muscle sensitivity to acetylcholine (ACh). miR-1 also regulates the muscle transcription factor MEF-2, which results in altered presynaptic ACh secretion, suggesting that MEF-2 activity in muscles controls a retrograde signal. The effect of the MEF-2-dependent retrograde signal on secretion is mediated by the synaptic vesicle protein RAB-3. Finally, acute activation of levamisole-sensitive nAChRs stimulates MEF-2-dependent transcriptional responses and induces the MEF-2-dependent retrograde signal. We propose that miR-1 refines synaptic function by coupling changes in muscle activity to changes in presynaptic function. KW - microrna AU - Simon, David AU - Madison, Jon AU - Conery, Annie AU - Thompson-Peer, Katherine AU - Soskis, Michael AU - Ruvkun, Gary AU - Kaplan, Joshua AU - Kim, John PY - 2008/05/30/ UR - http://dx.doi.org/10.1016/j.cell.2008.04.035 ER -