Cg-TGF-beta, a TGF-beta/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection. Export

@article{citeulike:2515178, abstract = {Transforming growth factor-beta (TGF-beta) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of Crassostrea gigas-TGF-beta (Cg-TGF-beta), a homologue of vertebrate TGF-beta and activin, from the bivalve mollusc C. gigas. Phylogenetic analysis suggests an early ancestral origin of this subgroup of TGF-beta superfamily member. Investigation of the spatio-temporal expression of Cg-TGF-beta gene by real-time quantitative RT-PCR showed a ubiquitous pattern in all adult tissues. These findings imply that Cg-TGF-beta has multiple functions as described for its vertebrate counterparts. Moreover, Cg-TGF-beta was upregulated in haemocytes during infection by a Gram-negative bacterium, suggesting that it could act as a cytokine involved in immunity in molluscs.}, author = {Lelong, C. and Badariotti, F. and Le Qu\'{e}r\'{e}, H. and Rodet, F. and Dubos, M. P. and Favrel, P.}, citeulike-article-id = {2515178}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.dci.2006.05.005}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16820208}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16820208}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T5X-4K66BP4-2/2/fd1d27dbdecedf11381c8724edc98d3e}, doi = {10.1016/j.dci.2006.05.005}, issn = {0145-305X}, journal = {Developmental and comparative immunology}, keywords = {crassostrea-gigas, tgfb}, number = {1}, pages = {30--38}, posted-at = {2008-03-11 14:41:00}, priority = {2}, title = {Cg-TGF-beta, a TGF-beta/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection.}, url = {http://dx.doi.org/10.1016/j.dci.2006.05.005}, volume = {31}, year = {2007} }

TY - JOUR ID - citeulike:2515178 L3 - citeulike-article-id:2515178 N2 - Transforming growth factor-beta (TGF-beta) members represent a widespread protein superfamily in the animal kingdom, but few members have been characterised in lophotrochozoans, a major clade of invertebrates. Here, we report the identification of Crassostrea gigas-TGF-beta (Cg-TGF-beta), a homologue of vertebrate TGF-beta and activin, from the bivalve mollusc C. gigas. Phylogenetic analysis suggests an early ancestral origin of this subgroup of TGF-beta superfamily member. Investigation of the spatio-temporal expression of Cg-TGF-beta gene by real-time quantitative RT-PCR showed a ubiquitous pattern in all adult tissues. These findings imply that Cg-TGF-beta has multiple functions as described for its vertebrate counterparts. Moreover, Cg-TGF-beta was upregulated in haemocytes during infection by a Gram-negative bacterium, suggesting that it could act as a cytokine involved in immunity in molluscs. IS - 1 JF - Developmental and comparative immunology SN - 0145-305X EP - 38 TI - Cg-TGF-beta, a TGF-beta/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection. VL - 31 SP - 30 KW - crassostrea-gigas KW - tgfb AU - Lelong, C AU - Badariotti, F AU - Le Quéré, H AU - Rodet, F AU - Dubos, MP AU - Favrel, P PY - 2007/// UR - http://dx.doi.org/10.1016/j.dci.2006.05.005 ER -