Transforming growth factor-[beta]-related proteins: an ancestral and widespread superfamily of cytokines in metazoans Export

@article{citeulike:2515186, abstract = {Members of the transforming growth factor [beta] (TGF-[beta]) superfamily of cell signalling polypeptides have attracted much attention because of their ability, from nematodes to mammals, to control cellular functions that in turn, regulate embryo development and tissue homeostasis. On the basis of structure similarities, the TGF-[beta] members (ligands, receptors and Smads) are subdivided into TGF-[beta] sensu stricto, bone morphogenetic proteins (BMP) and activins. Although BMP is the best characterized pathway in metazoans, recent findings in molluscs and non-bilateria as well as the analysis of nematode and arthropod genomes, demonstrate the early origin of these distinct subfamilies of ligands, receptors and Smads. This report analyses the large diversity of ligands, receptors and Smads in metazoans from cnidarians and molluscs to mammals. The contribution of new data, mainly from the lophochotrozoan Crassostrea gigas and other organisms on the fringe of the `branded model organisms', will help us to demonstrate that TGF-[beta]s are probably the most ancestral active cytokines characterized at the molecular level in both Protostome and Deuterostome lineages.}, author = {Herpin, Amaury and Lelong, Christophe and Favrel, Pascal}, booktitle = {Cytokines- an evolutionary perspective}, citeulike-article-id = {2515186}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.dci.2003.09.007}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15062644}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15062644}, citeulike-linkout-3 = {http://www.sciencedirect.com/science/article/B6T5X-49S6RR0-2/2/8aa5cd0b81769c9623fb8b2f8c4043fe}, day = {3}, doi = {10.1016/j.dci.2003.09.007}, journal = {Developmental \& Comparative Immunology}, keywords = {bmp, crassostrea-gigas, receptors, signalisation, smads, tgfb}, month = {May}, number = {5}, pages = {461--485}, posted-at = {2008-03-11 14:43:13}, priority = {0}, title = {Transforming growth factor-[beta]-related proteins: an ancestral and widespread superfamily of cytokines in metazoans}, url = {http://dx.doi.org/10.1016/j.dci.2003.09.007}, volume = {28}, year = {2004} }

TY - JOUR ID - citeulike:2515186 L3 - citeulike-article-id:2515186 N2 - Members of the transforming growth factor [beta] (TGF-[beta]) superfamily of cell signalling polypeptides have attracted much attention because of their ability, from nematodes to mammals, to control cellular functions that in turn, regulate embryo development and tissue homeostasis. On the basis of structure similarities, the TGF-[beta] members (ligands, receptors and Smads) are subdivided into TGF-[beta] sensu stricto, bone morphogenetic proteins (BMP) and activins. Although BMP is the best characterized pathway in metazoans, recent findings in molluscs and non-bilateria as well as the analysis of nematode and arthropod genomes, demonstrate the early origin of these distinct subfamilies of ligands, receptors and Smads. This report analyses the large diversity of ligands, receptors and Smads in metazoans from cnidarians and molluscs to mammals. The contribution of new data, mainly from the lophochotrozoan Crassostrea gigas and other organisms on the fringe of the `branded model organisms', will help us to demonstrate that TGF-[beta]s are probably the most ancestral active cytokines characterized at the molecular level in both Protostome and Deuterostome lineages. IS - 5 JF - Developmental & Comparative Immunology EP - 485 TI - Transforming growth factor-[beta]-related proteins: an ancestral and widespread superfamily of cytokines in metazoans VL - 28 T2 - Cytokines- an evolutionary perspective SP - 461 KW - bmp KW - crassostrea-gigas KW - receptors KW - signalisation KW - smads KW - tgfb AU - Herpin, Amaury AU - Lelong, Christophe AU - Favrel, Pascal PY - 2004/05/03/ UR - http://dx.doi.org/10.1016/j.dci.2003.09.007 ER -