Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Export

@article{citeulike:2742578, abstract = {Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily. Several members of this family have been shown to transduce their signals through binding to type I and type II serine-(threonine) kinase receptors. Here we report the cDNA cloning and characterization of a human type II receptor for BMPs (BMPR-II), which is distantly related to DAF-4, a BMP type II receptor from Caenorhabditis elegans. In transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to BMPR-II. BMPR-II bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type I receptors for BMPs. Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7.}, address = {Synergen, Inc., Boulder, CO 80301-2546, USA.}, author = {Rosenzweig, B. L. and Imamura, T. and Okadome, T. and Cox, G. N. and Yamashita, H. and ten Dijke, P. and Heldin, C. H. and Miyazono, K.}, citeulike-article-id = {2742578}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7644468}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7644468}, day = {15}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {bmp, receptors, signalisation, vertebre}, month = {August}, number = {17}, pages = {7632--7636}, posted-at = {2008-05-01 13:29:04}, priority = {4}, title = {Cloning and characterization of a human type II receptor for bone morphogenetic proteins.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7644468}, volume = {92}, year = {1995} }

TY - JOUR ID - citeulike:2742578 L3 - citeulike-article-id:2742578 N2 - Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily. Several members of this family have been shown to transduce their signals through binding to type I and type II serine-(threonine) kinase receptors. Here we report the cDNA cloning and characterization of a human type II receptor for BMPs (BMPR-II), which is distantly related to DAF-4, a BMP type II receptor from Caenorhabditis elegans. In transfected COS-1 cells, osteogenic protein (OP)-1/BMP-7, and less efficiently BMP-4, bound to BMPR-II. BMPR-II bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type I receptors for BMPs. Binding of OP-1/BMP-7 to BMPR-II was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by BMPR-II in the presence of type I receptors after stimulation by OP-1/BMP-7. IS - 17 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Synergen, Inc., Boulder, CO 80301-2546, USA. EP - 7636 TI - Cloning and characterization of a human type II receptor for bone morphogenetic proteins. VL - 92 SP - 7632 KW - bmp KW - receptors KW - signalisation KW - vertebre AU - Rosenzweig, BL AU - Imamura, T AU - Okadome, T AU - Cox, GN AU - Yamashita, H AU - ten Dijke, P AU - Heldin, CH AU - Miyazono, K PY - 1995/08/15/ UR - http://view.ncbi.nlm.nih.gov/pubmed/7644468 ER -