Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth. Export

@article{citeulike:3814622, abstract = {Bone morphogenetic proteins (BMPs) can either promote growth of embryonic muscle by expanding the Pax-3-expressing muscle precursor population or restrict its development by inducing apoptosis. Follistatin, a proposed BMP antagonist, is expressed in embryonic muscle. Deficiency in Follistatin results in muscle defects and postnatal asphyxia. Here, we report that during chick limb development Follistatin enhances BMP-7 action to induce muscle growth but prevents the ability of BMP-7 to induce apoptosis and muscle loss. Follistatin, unlike another BMP-binding protein, Noggin, promotes Pax-3 expression and transiently delays muscle differentiation and thus exerts proliferative signalling during muscle development. We provide data which show that Follistatin binds BMP-7 and BMP-2 at low affinities and that the binding is reversible. These data suggest that Follistatin acts to present BMPs to myogenic cells at a concentration that permits stimulation of embryonic muscle growth.}, author = {Amthor, H. and Christ, B. and Rashid-Doubell, F. and Kemp, C. F. and Lang, E. and Patel, K.}, citeulike-article-id = {3814622}, citeulike-linkout-0 = {http://dx.doi.org/10.1006/dbio.2001.0555}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/11846481}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=11846481}, day = {1}, doi = {10.1006/dbio.2001.0555}, issn = {0012-1606}, journal = {Developmental biology}, keywords = {crassostrea-gigas}, month = {March}, number = {1}, pages = {115--127}, posted-at = {2008-12-20 15:57:57}, priority = {2}, title = {Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth.}, url = {http://dx.doi.org/10.1006/dbio.2001.0555}, volume = {243}, year = {2002} }

TY - JOUR ID - citeulike:3814622 L3 - citeulike-article-id:3814622 N2 - Bone morphogenetic proteins (BMPs) can either promote growth of embryonic muscle by expanding the Pax-3-expressing muscle precursor population or restrict its development by inducing apoptosis. Follistatin, a proposed BMP antagonist, is expressed in embryonic muscle. Deficiency in Follistatin results in muscle defects and postnatal asphyxia. Here, we report that during chick limb development Follistatin enhances BMP-7 action to induce muscle growth but prevents the ability of BMP-7 to induce apoptosis and muscle loss. Follistatin, unlike another BMP-binding protein, Noggin, promotes Pax-3 expression and transiently delays muscle differentiation and thus exerts proliferative signalling during muscle development. We provide data which show that Follistatin binds BMP-7 and BMP-2 at low affinities and that the binding is reversible. These data suggest that Follistatin acts to present BMPs to myogenic cells at a concentration that permits stimulation of embryonic muscle growth. IS - 1 JF - Developmental biology SN - 0012-1606 EP - 127 TI - Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth. VL - 243 SP - 115 KW - crassostrea-gigas AU - Amthor, H AU - Christ, B AU - Rashid-Doubell, F AU - Kemp, CF AU - Lang, E AU - Patel, K PY - 2002/03/01/ UR - http://dx.doi.org/10.1006/dbio.2001.0555 ER -