Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Export

@article{citeulike:953456, abstract = {TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus.}, address = {Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA. yshi@molbio.princeton.edu}, author = {Shi, Yigong and Massagu\'{e}, Joan}, citeulike-article-id = {953456}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12809600}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12809600}, day = {13}, issn = {0092-8674}, journal = {Cell}, keywords = {receptors, signalisation, smads, tgfb}, month = {June}, number = {6}, pages = {685--700}, posted-at = {2008-03-11 15:25:58}, priority = {2}, title = {Mechanisms of TGF-beta signaling from cell membrane to the nucleus.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12809600}, volume = {113}, year = {2003} }

TY - JOUR ID - citeulike:953456 L3 - citeulike-article-id:953456 N2 - TGF-beta signaling controls a plethora of cellular responses and figures prominently in animal development. Recent cellular, biochemical, and structural studies have revealed significant insight into the mechanisms of the activation of TGF-beta receptors through ligand binding, the activation of Smad proteins through phosphorylation, the transcriptional regulation of target gene expression, and the control of Smad protein activity and degradation. This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus. IS - 6 JF - Cell SN - 0092-8674 AD - Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544, USA. yshi@molbio.princeton.edu EP - 700 TI - Mechanisms of TGF-beta signaling from cell membrane to the nucleus. VL - 113 SP - 685 KW - receptors KW - signalisation KW - smads KW - tgfb AU - Shi, Yigong AU - Massagué, Joan PY - 2003/06/13/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12809600 ER -