Identification of Lead Compounds As Antagonists of Protein Bcl-xL with a Diversity-Oriented Multidisciplinary Approach Export

@article{citeulike:6060695, abstract = {PMID: 19852471 We report on the use of a diversity oriented synthesis (DOS) approach that resulted in the generation of a set of libraries of compounds presenting novel structural cores. These chemical cores have been employed to design potential antagonists of the antiapoptotic protein Bcl-xL through reiterated steps of molecular docking calculations followed by experimental verification of binding. Our data suggest that the DOS approach is suitable to generate novel scaffolds, which can be employed to target protein−protein interactions.}, author = {Di Micco, Simone and Vitale, Romina and Pellecchia, Maurizio and Rega, Michele F. and Riva, Renata and Basso, Andrea and Bifulco, Giuseppe}, citeulike-article-id = {6060695}, citeulike-linkout-0 = {http://dx.doi.org/10.1021/jm9010687}, citeulike-linkout-1 = {http://pubs.acs.org/doi/abs/10.1021/jm9010687}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19852471}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19852471}, day = {23}, doi = {10.1021/jm9010687}, issn = {1520-4804}, journal = {Journal of Medicinal Chemistry}, keywords = {2009, bclxl, dos, ppi, sm, xf}, month = {October}, number = {0}, posted-at = {2009-11-03 16:43:30}, priority = {3}, title = {Identification of Lead Compounds As Antagonists of Protein Bcl-xL with a Diversity-Oriented Multidisciplinary Approach}, url = {http://dx.doi.org/10.1021/jm9010687}, volume = {0}, year = {0000} }

TY - JOUR ID - citeulike:6060695 L3 - citeulike-article-id:6060695 N2 - PMID: 19852471 We report on the use of a diversity oriented synthesis (DOS) approach that resulted in the generation of a set of libraries of compounds presenting novel structural cores. These chemical cores have been employed to design potential antagonists of the antiapoptotic protein Bcl-xL through reiterated steps of molecular docking calculations followed by experimental verification of binding. Our data suggest that the DOS approach is suitable to generate novel scaffolds, which can be employed to target protein−protein interactions. IS - 0 JF - Journal of Medicinal Chemistry SN - 1520-4804 TI - Identification of Lead Compounds As Antagonists of Protein Bcl-xL with a Diversity-Oriented Multidisciplinary Approach VL - 0 KW - 2009 KW - bclxl KW - dos KW - ppi KW - sm KW - xf AU - Di Micco, Simone AU - Vitale, Romina AU - Pellecchia, Maurizio AU - Rega, Michele AU - Riva, Renata AU - Basso, Andrea AU - Bifulco, Giuseppe PY - 2000/10/23/ UR - http://dx.doi.org/10.1021/jm9010687 ER -