Prefrontal white matter in pathological liars. Export

@article{citeulike:1054870, abstract = {BACKGROUND: Studies have shown increased bilateral activation in the prefrontal cortex when normal individuals lie, but there have been no structural imaging studies of deceitful individuals. AIMS: To assess whether deceitful individuals show structural abnormalities in prefrontal grey and white matter volume. METHOD: Prefrontal grey and white matter volumes were assessed using structural magnetic resonance imaging in 12 individuals who pathologically lie, cheat and deceive ('liars'),16 antisocial controls and 21 normal controls. RESULTS: Liars showed a 22-26\% increase in prefrontal white matter and a 36-42\% reduction in prefrontal grey/white ratios compared with both antisocial controls and normal controls. CONCLUSIONS: These findings provide the first evidence of a structural brain deficitinliars, they implicate the prefrontal cortex as an important (but not sole) component in the neural circuitry underlying lying and provide an initial neurobiological correlate of a deceitful personality.}, address = {Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA. yalingy@usc.edu}, author = {Yang, Y. and Raine, A. and Lencz, T. and Bihrle, S. and Lacasse, L. and Colletti, P.}, citeulike-article-id = {1054870}, citeulike-linkout-0 = {http://dx.doi.org/10.1192/bjp.187.4.320}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16199789}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16199789}, doi = {10.1192/bjp.187.4.320}, issn = {0007-1250}, journal = {Br J Psychiatry}, keywords = {liars, matter, neurology, pathological, psychiatry, white}, month = {October}, pages = {320--325}, posted-at = {2009-09-18 07:45:19}, priority = {2}, title = {Prefrontal white matter in pathological liars.}, url = {http://dx.doi.org/10.1192/bjp.187.4.320}, volume = {187}, year = {2005} }

TY - JOUR ID - citeulike:1054870 L3 - citeulike-article-id:1054870 N2 - BACKGROUND: Studies have shown increased bilateral activation in the prefrontal cortex when normal individuals lie, but there have been no structural imaging studies of deceitful individuals. AIMS: To assess whether deceitful individuals show structural abnormalities in prefrontal grey and white matter volume. METHOD: Prefrontal grey and white matter volumes were assessed using structural magnetic resonance imaging in 12 individuals who pathologically lie, cheat and deceive ('liars'),16 antisocial controls and 21 normal controls. RESULTS: Liars showed a 22-26% increase in prefrontal white matter and a 36-42% reduction in prefrontal grey/white ratios compared with both antisocial controls and normal controls. CONCLUSIONS: These findings provide the first evidence of a structural brain deficitinliars, they implicate the prefrontal cortex as an important (but not sole) component in the neural circuitry underlying lying and provide an initial neurobiological correlate of a deceitful personality. JF - Br J Psychiatry SN - 0007-1250 AD - Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA. yalingy@usc.edu EP - 325 TI - Prefrontal white matter in pathological liars. VL - 187 SP - 320 KW - liars KW - matter KW - neurology KW - pathological KW - psychiatry KW - white AU - Yang, Y AU - Raine, A AU - Lencz, T AU - Bihrle, S AU - Lacasse, L AU - Colletti, P PY - 2005/10// UR - http://dx.doi.org/10.1192/bjp.187.4.320 ER -