Overview of structure and function of mammalian cilia. Export

@article{citeulike:1896960, abstract = {Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane. Axonemes in multiciliated cells of mammalian epithelia are 9 + 2, possess dynein arms, and are motile. In contrast, single nonmotile 9 + 0 primary cilia are found on epithelial cells, such as those of the kidney tubule, but also on nonepithelial cells, such as chondrocytes, fibroblasts, and neurons. The ciliary membranes of all cilia contain specific receptors and ion channel proteins that initiate signaling pathways controlling motility and/or linking mechanical or chemical stimuli, including sonic hedgehog and growth factors, to intracellular transduction cascades regulating differentiation, migration, and cell growth during development and in adulthood. Unique motile 9 + 0 cilia, found during development at the embryonic node, determine left-right asymmetry of the body.}, address = {Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA. satir@aecom.yu.edu}, author = {Satir, P. and Christensen, S. T.}, citeulike-article-id = {1896960}, citeulike-linkout-0 = {http://dx.doi.org/10.1146/annurev.physiol.69.040705.141236}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17009929}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17009929}, doi = {10.1146/annurev.physiol.69.040705.141236}, issn = {0066-4278}, journal = {Annu Rev Physiol}, keywords = {lc4, thesis}, pages = {377--400}, posted-at = {2008-11-15 04:40:00}, priority = {2}, title = {Overview of structure and function of mammalian cilia.}, url = {http://dx.doi.org/10.1146/annurev.physiol.69.040705.141236}, volume = {69}, year = {2007} }

TY - JOUR ID - citeulike:1896960 L3 - citeulike-article-id:1896960 N2 - Cilia are membrane-bounded, centriole-derived projections from the cell surface that contain a microtubule cytoskeleton, the ciliary axoneme, surrounded by a ciliary membrane. Axonemes in multiciliated cells of mammalian epithelia are 9 + 2, possess dynein arms, and are motile. In contrast, single nonmotile 9 + 0 primary cilia are found on epithelial cells, such as those of the kidney tubule, but also on nonepithelial cells, such as chondrocytes, fibroblasts, and neurons. The ciliary membranes of all cilia contain specific receptors and ion channel proteins that initiate signaling pathways controlling motility and/or linking mechanical or chemical stimuli, including sonic hedgehog and growth factors, to intracellular transduction cascades regulating differentiation, migration, and cell growth during development and in adulthood. Unique motile 9 + 0 cilia, found during development at the embryonic node, determine left-right asymmetry of the body. JF - Annu Rev Physiol SN - 0066-4278 AD - Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA. satir@aecom.yu.edu EP - 400 TI - Overview of structure and function of mammalian cilia. VL - 69 SP - 377 KW - lc4 KW - thesis AU - Satir, P AU - Christensen, ST PY - 2007/// UR - http://dx.doi.org/10.1146/annurev.physiol.69.040705.141236 ER -