Differential expression of cell adhesion genes: implications for drug resistance Export

@article{15514970, abstract = {It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in suspension to similar cells grown attached to one another as aggregates have suggested that it is adhesion to the extracellular matrix of the basal membrane that confers resistance to apoptosis and, hence, resistance to cytotoxins. The genes whose expression correlates with poor survival might, therefore, act through such a matrix-to-cell suppression of apoptosis. Indeed, correlative mining of gene expression and patient survival databases suggests that poor survival in patients with metastatic cancer correlates highly with tumor expression of a common theme: the genes involved in cell adhesion and the cytoskeleton. If the proteins involved in tethering cells to the extracellular matrix are important in conferring drug resistance, it may be possible to improve chemotherapy by designing drugs that target these proteins.}, address = {Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel. wdstein@vms.huji.ac.il}, author = {Stein, W. D. and Litman, T. and Fojo, T. and Bates, S. E.}, citeulike-article-id = {4415814}, citeulike-linkout-0 = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15514970%20}, comment = {0020-7136 Journal Article Review Review, Tutorial}, day = {1}, journal = {Int J Cancer}, keywords = {adhesiongenetics, agentstherapeutic, analysis, antineoplastic, cell, divisiongenetics, drug, file-import-09-04-28, govt, humans, neoplasmgenetics, neoplasmsdrug, non-us, phs, research, resistance, support, survival, therapygeneticsmortalitypathology, us, use}, month = {March}, number = {6}, pages = {861--5}, posted-at = {2009-04-28 16:00:56}, priority = {2}, title = {Differential expression of cell adhesion genes: implications for drug resistance}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15514970%20}, volume = {113}, year = {2005} }

TY - JOUR ID - 15514970 L3 - citeulike-article-id:4415814 N2 - It is well known that tumors arising from tissues such as kidney, pancreas, liver and stomach are particularly refractory to treatment. Searching for new anticancer drugs using cells in culture has yielded some effective therapies, but these refractory tumors remain intractable. Studies that compare cells grown in suspension to similar cells grown attached to one another as aggregates have suggested that it is adhesion to the extracellular matrix of the basal membrane that confers resistance to apoptosis and, hence, resistance to cytotoxins. The genes whose expression correlates with poor survival might, therefore, act through such a matrix-to-cell suppression of apoptosis. Indeed, correlative mining of gene expression and patient survival databases suggests that poor survival in patients with metastatic cancer correlates highly with tumor expression of a common theme: the genes involved in cell adhesion and the cytoskeleton. If the proteins involved in tethering cells to the extracellular matrix are important in conferring drug resistance, it may be possible to improve chemotherapy by designing drugs that target these proteins. IS - 6 JF - Int J Cancer AD - Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel. wdstein@vms.huji.ac.il EP - 5 TI - Differential expression of cell adhesion genes: implications for drug resistance VL - 113 SP - 861 KW - adhesiongenetics KW - agentstherapeutic KW - analysis KW - antineoplastic KW - cell KW - divisiongenetics KW - drug KW - file-import-09-04-28 KW - govt KW - humans KW - neoplasmgenetics KW - neoplasmsdrug KW - non-us KW - phs KW - research KW - resistance KW - support KW - survival KW - therapygeneticsmortalitypathology KW - us KW - use N1 - 0020-7136 Journal Article Review Review, Tutorial AU - Stein, WD AU - Litman, T AU - Fojo, T AU - Bates, SE PY - 2005/03/01/ UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15514970%20 ER -