Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme Export

@article{15827123, abstract = {Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We investigated global gene expression in surgical samples of brain tumors. Gene expression profiling revealed large differences between normal brain samples and tumor tissues and between GBMs and lower-grade oligodendroglial tumors. Extensive differences in gene expression were found among GBMs, particularly in genes involved in angiogenesis, immune cell infiltration, and extracellular matrix remodeling. We found that the gene expression patterns in paired specimens from the same GBM invariably were more closely related to each other than to any other tumor, even when the paired specimens had strikingly divergent histologies. Survival analyses revealed a set of approximately 70 genes more highly expressed in rapidly progressing tumors that stratified GBMs into two groups that differed by >4-fold in median duration of survival. We further investigated one gene from the group, FABP7, and confirmed its association with survival in two unrelated cohorts totaling 105 patients. Expression of FABP7 enhanced the motility of glioma-derived cells in vitro. Our analyses thus identify and validate a prognostic marker of both biologic and clinical significance and provide a series of putative markers for additional evaluation.}, address = {Preuss Laboratory for Molecular Neuro-oncology and Departments of Neurological Surgery and Pathology, University of California, San Francisco, CA 94143.}, author = {Liang, Y. and Diehn, M. and Watson, N. and Bollen, A. W. and Aldape, K. D. and Nicholas, M. K. and Lamborn, K. R. and Berger, M. S. and Botstein, D. and Brown, P. O. and Israel, M. A.}, citeulike-article-id = {4416073}, citeulike-linkout-0 = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15827123%20}, comment = {0027-8424 Journal Article}, journal = {Proc Natl Acad Sci U S A}, keywords = {file-import-09-04-28}, month = {April}, number = {16}, pages = {5814--9}, posted-at = {2009-04-28 16:01:55}, priority = {2}, title = {Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15827123%20}, volume = {102}, year = {2005} }

TY - JOUR ID - 15827123 L3 - citeulike-article-id:4416073 N2 - Glioblastoma multiforme (GBM) is the most common form of malignant glioma, characterized by genetic instability, intratumoral histopathological variability, and unpredictable clinical behavior. We investigated global gene expression in surgical samples of brain tumors. Gene expression profiling revealed large differences between normal brain samples and tumor tissues and between GBMs and lower-grade oligodendroglial tumors. Extensive differences in gene expression were found among GBMs, particularly in genes involved in angiogenesis, immune cell infiltration, and extracellular matrix remodeling. We found that the gene expression patterns in paired specimens from the same GBM invariably were more closely related to each other than to any other tumor, even when the paired specimens had strikingly divergent histologies. Survival analyses revealed a set of approximately 70 genes more highly expressed in rapidly progressing tumors that stratified GBMs into two groups that differed by >4-fold in median duration of survival. We further investigated one gene from the group, FABP7, and confirmed its association with survival in two unrelated cohorts totaling 105 patients. Expression of FABP7 enhanced the motility of glioma-derived cells in vitro. Our analyses thus identify and validate a prognostic marker of both biologic and clinical significance and provide a series of putative markers for additional evaluation. IS - 16 JF - Proc Natl Acad Sci U S A AD - Preuss Laboratory for Molecular Neuro-oncology and Departments of Neurological Surgery and Pathology, University of California, San Francisco, CA 94143. EP - 9 TI - Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme VL - 102 SP - 5814 KW - file-import-09-04-28 N1 - 0027-8424 Journal Article AU - Liang, Y AU - Diehn, M AU - Watson, N AU - Bollen, AW AU - Aldape, KD AU - Nicholas, MK AU - Lamborn, KR AU - Berger, MS AU - Botstein, D AU - Brown, PO AU - Israel, MA PY - 2005/04/19/ UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15827123%20 ER -