ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex Export

@article{citeulike:1947249, abstract = {The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery. 10.1126/science.1090701}, author = {Mizuguchi, Gaku and Shen, Xuetong and Landry, Joe and Wu, Wei-Hua and Sen, Subhojit and Wu, Carl}, citeulike-article-id = {1947249}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1090701}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/303/5656/343}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/14645854}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=14645854}, day = {16}, doi = {10.1126/science.1090701}, journal = {Science}, keywords = {exchange, histone, swc1, swc3}, month = {January}, number = {5656}, pages = {343--348}, posted-at = {2007-11-20 22:05:04}, priority = {5}, title = {ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex}, url = {http://dx.doi.org/10.1126/science.1090701}, volume = {303}, year = {2004} }

TY - JOUR ID - citeulike:1947249 L3 - citeulike-article-id:1947249 N2 - The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. We have found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery. 10.1126/science.1090701 IS - 5656 JF - Science EP - 348 TI - ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex VL - 303 SP - 343 KW - exchange KW - histone KW - swc1 KW - swc3 AU - Mizuguchi, Gaku AU - Shen, Xuetong AU - Landry, Joe AU - Wu, Wei-Hua AU - Sen, Subhojit AU - Wu, Carl PY - 2004/01/16/ UR - http://dx.doi.org/10.1126/science.1090701 ER -