Dynamic interactions of proteins in complex networks: a more structured view Export

@article{citeulike:5809332, abstract = {Virtually every process in a cell is carried out by macromolecular complexes whose actions need to be perfectly orchestrated. The synchronization and regulation of these biological functions is indeed critical and is usually carried out by complex networks of transient protein interactions. Here, we review some of the many strategies that proteins in regulatory networks use to achieve the dynamic plasticity necessary to rapidly respond to diverse cellular needs. More specifically, we present recent work on the molecular bases of transient peptide-mediated interactions and the role that post-translational modifications and disordered regions might play. Finally, in light of some recent findings, we speculate on the possibility of a new regulatory code for intrinsically disordered proteins and the potential biophysical and functional advantages that disorder might provide.}, address = {Institute for Research in Biomedicine, Barcelona, Spain; Barcelona Supercomputing Center, Spain; Departament de Qumica Orgnica, Universitat de Barcelona, Spain; Instituci Catalana de Recerca i Estudis Avanats, Barcelona, Spain}, author = {Stein, Amelie and Pache, Roland A. and Bernad\'{o}, Pau and Pons, Miquel and Aloy, Patrick}, citeulike-article-id = {5809332}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1742-4658.2009.07251.x}, citeulike-linkout-1 = {http://www.ingentaconnect.com/content/bsc/ejb/2009/00000276/00000019/art00008}, citeulike-linkout-2 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122579430/ABSTRACT}, doi = {10.1111/j.1742-4658.2009.07251.x}, issn = {1742-4658}, journal = {FEBS Journal}, keywords = {protein-structure}, number = {19}, pages = {5390--5405}, posted-at = {2009-10-21 12:11:38}, priority = {0}, publisher = {Blackwell Publishing}, title = {Dynamic interactions of proteins in complex networks: a more structured view}, url = {http://dx.doi.org/10.1111/j.1742-4658.2009.07251.x}, volume = {276}, year = {2009} }

TY - JOUR ID - citeulike:5809332 L3 - citeulike-article-id:5809332 N2 - Virtually every process in a cell is carried out by macromolecular complexes whose actions need to be perfectly orchestrated. The synchronization and regulation of these biological functions is indeed critical and is usually carried out by complex networks of transient protein interactions. Here, we review some of the many strategies that proteins in regulatory networks use to achieve the dynamic plasticity necessary to rapidly respond to diverse cellular needs. More specifically, we present recent work on the molecular bases of transient peptide-mediated interactions and the role that post-translational modifications and disordered regions might play. Finally, in light of some recent findings, we speculate on the possibility of a new regulatory code for intrinsically disordered proteins and the potential biophysical and functional advantages that disorder might provide. IS - 19 JF - FEBS Journal SN - 1742-4658 AD - Institute for Research in Biomedicine, Barcelona, Spain; Barcelona Supercomputing Center, Spain; Departament de Qumica Orgnica, Universitat de Barcelona, Spain; Instituci Catalana de Recerca i Estudis Avanats, Barcelona, Spain EP - 5405 TI - Dynamic interactions of proteins in complex networks: a more structured view PB - Blackwell Publishing VL - 276 SP - 5390 KW - protein-structure AU - Stein, Amelie AU - Pache, Roland AU - Bernadó, Pau AU - Pons, Miquel AU - Aloy, Patrick PY - 2009/// UR - http://dx.doi.org/10.1111/j.1742-4658.2009.07251.x ER -